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• W2897734194 abstract "One of the most important microvasculatures’ geometrical variables is number of pores per capillary length that can be evaluated using MRI. The transportation of blood from inner to outer parts of the capillary is studied by the pores and the relationship among capillary wall thickness, size and the number of pores is examined. Characterization of capillary space may obtain much valuable information on the performance of tissues as well as the angiogenesis. To estimate the number of pores, a new pseudo-liquid drop model along with appropriate quantitative physiological purposes has been investigated toward indicating a package of data on the capillary space. This model has utilized the MRI perfusion, diffusion and relaxivity parameters such as cerebral blood volume (CBV), apparent diffusion coefficient (ADC), ΔR2 and ΔR2* values. To verify the model, a special protocol was designed and tested on various regions of eight male Wistar rats. The maximum number of pores per capillary length in the various conditions such as recovery, core, normal-recovery, and normal-core were found to be 183 ± 146, 176 ± 160, 275 ± 166, and 283 ± 143, respectively. This ratio in the normal regions was more than that of the damaged ones. The number of pores increased with increasing mean radius of the capillary and decreasing the thickness of the wall in the capillary space. Determination of the number of capillary pore may most likely help to evaluate angiogenesis in the tissues and treatment planning of abnormal ones." @default.
• W2897734194 created "2018-10-26" @default.
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• W2897734194 date "2019-01-01" @default.
• W2897734194 modified "2023-09-26" @default.
• W2897734194 title "Estimation of microvascular capillary physical parameters using MRI assuming a pseudo liquid drop as model of fluid exchange on the cellular level" @default.
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• W2897734194 doi "https://doi.org/10.1016/j.rpor.2018.09.007" @default.
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