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• W2897734852 endingPage "285" @default.
• W2897734852 startingPage "275" @default.
• W2897734852 abstract "Polycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems. Its catalytic subunit EZH2 represents a key nuclear target for long non-coding RNAs (lncRNAs) that emerging to be a novel class of epigenetic regulator and participate in diverse cellular processes. LncRNAs are characterized by high tissue-specificity; however, little is known about the tissue profile of the EZH2- interacting lncRNAs.Here we performed a global screening for EZH2-binding lncRNAs in tissues including brain, lung, heart, liver, kidney, intestine, spleen, testis, muscle and blood by combining RNA immuno- precipitation and RNA sequencing. We identified 1328 EZH2-binding lncRNAs, among which 470 were shared in at least two tissues while 858 were only detected in single tissue. An RNA motif with specific secondary structure was identified in a number of lncRNAs, albeit not in all EZH2-binding lncRNAs. The EZH2-binding lncRNAs fell into four categories including intergenic lncRNA, antisense lncRNA, intron-related lncRNA and promoter-related lncRNA, suggesting diverse regulations of both cis and trans-mechanisms. A promoter-related lncRNA Hnf1aos1 bound to EZH2 specifically in the liver, a feature same as its paired coding gene Hnf1a, further confirming the validity of our study. In addition to the well known EZH2-binding lncRNAs like Kcnq1ot1, Gas5, Meg3, Hotair and Malat1, majority of the lncRNAs were firstly reported to be associated with EZH2.Our findings provide a profiling view of the EZH2-interacting lncRNAs across different tissues, and suggest critical roles of lncRNAs during cell differentiation and maturation." @default.
• W2897734852 created "2018-10-26" @default.
• W2897734852 creator A5003642180 @default.
• W2897734852 creator A5014661038 @default.
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• W2897734852 creator A5036834791 @default.
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• W2897734852 creator A5054391201 @default.
• W2897734852 creator A5063811482 @default.
• W2897734852 date "2018-11-12" @default.
• W2897734852 modified "2023-10-17" @default.
• W2897734852 title "EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs" @default.
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• W2897734852 doi "https://doi.org/10.2174/1566523218666181008125010" @default.
• W2897734852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6249712" @default.

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