FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897735873> ?p ?o ?g. }

• W2897735873 endingPage "5569" @default.
• W2897735873 startingPage "5558" @default.
• W2897735873 abstract "Abstract Purvalanol and roscovitine are specific cyclin‐dependent kinase (CDK) inhibitors, which have antiproliferative and apoptotic effects on various types of cancer. Although, the apoptotic accomplishment of purvalanol and roscovitine was elucidated at the molecular level, the underlying exact of drug‐induced apoptosis through mitogen‐activated protein kinase (MAPK) signaling still speculative. In addition, the role of CDK inhibitors in the downregulation of extracellular signal–regulated kinase 1/2 (ERK1/2)‐mediated epithelial‐mesenchymal transition (EMT) remains unclear. Here, we investigated the potential effect of each CDK inhibitors on cell proliferation, migration, and generation of reactive oxygen species due to the inhibition of MAPKs in metastatic DU145 and PC3 prostate cancer cells. We reported that purvalanol and roscovitine induced mitochondria membrane potential loss–dependent apoptotic cell death, which was also characterized by activation of several caspases, cleavage of poly (ADP‐ribose) polymerase‐1 in DU145 and PC3 cells. Cotreatment of either purvalanol or roscovitine with ERK1/2 inhibitor, U0126, synergistically suppressed cell proliferation, and induced apoptotic action. Also, ERK1/2 inhibition potentiated the effect of each CDK inhibitor on the downregulation of EMT processes via increasing the epithelial marker and decreasing mesenchymal markers through reduction of Wnt signaling regulators in DU145 cells. This study provides biological evidence about purvalanol and roscovitine have apoptotic and antimetastatic effects via MAPK signaling on prostate cancer cell by activation of GSK3β signaling and inhibition of phosphoinositide‐3‐kinase/AKT (PI3K/AKT) pathways involved in the EMT process." @default.
• W2897735873 created "2018-10-26" @default.
• W2897735873 creator A5003490576 @default.
• W2897735873 creator A5022805141 @default.
• W2897735873 creator A5028719443 @default.
• W2897735873 creator A5044461989 @default.
• W2897735873 creator A5080689896 @default.
• W2897735873 creator A5089098896 @default.
• W2897735873 date "2018-10-15" @default.
• W2897735873 modified "2023-09-25" @default.
• W2897735873 title "Inhibition of extracellular signal‐regulated kinase potentiates the apoptotic and antimetastatic effects of cyclin‐dependent kinase inhibitors on metastatic DU145 and PC3 prostate cancer cells" @default.
• W2897735873 cites W1975131304 @default.
• W2897735873 cites W1978785485 @default.
• W2897735873 cites W1985297286 @default.
• W2897735873 cites W1995864606 @default.
• W2897735873 cites W2011685758 @default.
• W2897735873 cites W2055587059 @default.
• W2897735873 cites W2056907950 @default.
• W2897735873 cites W2058468989 @default.
• W2897735873 cites W2063988637 @default.
• W2897735873 cites W2068405904 @default.
• W2897735873 cites W2073497404 @default.
• W2897735873 cites W2081138086 @default.
• W2897735873 cites W2087523610 @default.
• W2897735873 cites W2105651504 @default.
• W2897735873 cites W2150670229 @default.
• W2897735873 cites W2163188200 @default.
• W2897735873 cites W2171054569 @default.
• W2897735873 cites W2318564252 @default.
• W2897735873 cites W2322210753 @default.
• W2897735873 cites W2344212242 @default.
• W2897735873 cites W2407520682 @default.
• W2897735873 cites W2476470567 @default.
• W2897735873 cites W2493101410 @default.
• W2897735873 cites W2570618306 @default.
• W2897735873 cites W2717569083 @default.
• W2897735873 cites W2740089004 @default.
• W2897735873 cites W2782486727 @default.
• W2897735873 cites W2803785278 @default.
• W2897735873 doi "https://doi.org/10.1002/jcb.27840" @default.
• W2897735873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320903" @default.
• W2897735873 hasPublicationYear "2018" @default.
• W2897735873 type Work @default.
• W2897735873 sameAs 2897735873 @default.
• W2897735873 citedByCount "2" @default.
• W2897735873 countsByYear W28977358732019 @default.
• W2897735873 countsByYear W28977358732021 @default.
• W2897735873 crossrefType "journal-article" @default.
• W2897735873 hasAuthorship W2897735873A5003490576 @default.
• W2897735873 hasAuthorship W2897735873A5022805141 @default.
• W2897735873 hasAuthorship W2897735873A5028719443 @default.
• W2897735873 hasAuthorship W2897735873A5044461989 @default.
• W2897735873 hasAuthorship W2897735873A5080689896 @default.
• W2897735873 hasAuthorship W2897735873A5089098896 @default.
• W2897735873 hasConcept C121608353 @default.
• W2897735873 hasConcept C124320809 @default.
• W2897735873 hasConcept C184235292 @default.
• W2897735873 hasConcept C190283241 @default.
• W2897735873 hasConcept C2776438761 @default.
• W2897735873 hasConcept C2779723316 @default.
• W2897735873 hasConcept C29537977 @default.
• W2897735873 hasConcept C502942594 @default.
• W2897735873 hasConcept C54355233 @default.
• W2897735873 hasConcept C55493867 @default.
• W2897735873 hasConcept C57074206 @default.
• W2897735873 hasConcept C62112901 @default.
• W2897735873 hasConcept C62478195 @default.
• W2897735873 hasConcept C75217442 @default.
• W2897735873 hasConcept C86554907 @default.
• W2897735873 hasConcept C86803240 @default.
• W2897735873 hasConcept C95444343 @default.
• W2897735873 hasConcept C96232424 @default.
• W2897735873 hasConceptScore W2897735873C121608353 @default.
• W2897735873 hasConceptScore W2897735873C124320809 @default.
• W2897735873 hasConceptScore W2897735873C184235292 @default.
• W2897735873 hasConceptScore W2897735873C190283241 @default.
• W2897735873 hasConceptScore W2897735873C2776438761 @default.
• W2897735873 hasConceptScore W2897735873C2779723316 @default.
• W2897735873 hasConceptScore W2897735873C29537977 @default.
• W2897735873 hasConceptScore W2897735873C502942594 @default.
• W2897735873 hasConceptScore W2897735873C54355233 @default.
• W2897735873 hasConceptScore W2897735873C55493867 @default.
• W2897735873 hasConceptScore W2897735873C57074206 @default.
• W2897735873 hasConceptScore W2897735873C62112901 @default.
• W2897735873 hasConceptScore W2897735873C62478195 @default.
• W2897735873 hasConceptScore W2897735873C75217442 @default.
• W2897735873 hasConceptScore W2897735873C86554907 @default.
• W2897735873 hasConceptScore W2897735873C86803240 @default.
• W2897735873 hasConceptScore W2897735873C95444343 @default.
• W2897735873 hasConceptScore W2897735873C96232424 @default.
• W2897735873 hasIssue "4" @default.
• W2897735873 hasLocation W28977358731 @default.
• W2897735873 hasLocation W28977358732 @default.
• W2897735873 hasOpenAccess W2897735873 @default.
• W2897735873 hasPrimaryLocation W28977358731 @default.
• W2897735873 hasRelatedWork W1985116866 @default.
• W2897735873 hasRelatedWork W2004726042 @default.
• W2897735873 hasRelatedWork W2030981986 @default.

• next