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- W2897740166 abstract "The cell wall is a structure external to the plasma membrane that is essential for the survival of the fungi. This polysaccharidic structure confers resistance to the cell internal turgor pressure and protection against mechanical injury. The fungal wall is also responsible for the shape of these organisms due to different structural polysaccharides, such as β-(1,3)-glucan, which form fibers and confer rigidity to the cell wall. These polysaccharides are not present in animal cells and therefore they constitute excellent targets for antifungal chemotherapies. Cell wall damage leads to the activation of MAPK signaling pathways, which respond to the damage by activating the repair of the wall and the maintenance of the cell integrity. Fission yeast Schizosaccharomyces pombe is a model organism for the study morphogenesis, cell wall, and how different inputs might regulate this structure. We present here a short overview of the fission yeast wall composition and provide information about the main biosynthetic activities that assemble this cell wall. Additionally, we comment the recent advances in the knowledge of the cell wall functions and discuss the role of the cell integrity MAPK signaling pathway in the regulation of fission yeast wall." @default.
- W2897740166 created "2018-10-26" @default.
- W2897740166 creator A5024082362 @default.
- W2897740166 creator A5035741583 @default.
- W2897740166 creator A5040903381 @default.
- W2897740166 creator A5076547080 @default.
- W2897740166 date "2018-12-01" @default.
- W2897740166 modified "2023-10-18" @default.
- W2897740166 title "Fission yeast cell wall biosynthesis and cell integrity signalling" @default.
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