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• W2897740922 abstract "Previous work suggests that cognitively unimpaired (CU) late middle-aged adults with amyloid deposition demonstrate greater verbal learning and memory decline. Less is known about the relationship between neurodegeneration and verbal learning and memory decline in this group. The purpose of this study was to examine the effect of neurodegeneration, and its interaction with amyloid, on longitudinal verbal learning and memory performance. Data were from 329 CU late middle-aged adults (Table 1). Participants completed 1+ biomarker visits and 2-5 neuropsychological evaluations. Amyloid deposition was assessed using cerebrospinal fluid (CSF) AB42 levels. Neurodegeneration was estimated using hippocampal volume (estimates derived in FSL FIRST) and global atrophy (ratio of CSF to brain volume; obtained using SPM12). Longitudinal verbal list learning and delayed recall (i.e., memory) were assessed using Rey Auditory Verbal Learning Test (RAVLT). Linear mixed effects regression models including covariates (age and education) and random effects (subject-specific intercept and age-related slope) examined effects of neurodegeneration and amyloid deposition on age-related decline. Sequential likelihood ratio tests of nested models were used to assess statistical significance. Results are interpreted for highest model number in which additional terms were significant. Global atrophy was a significant predictor of learning (Model 3, Table 2) and delayed recall (Model 3, Table 3), after adjusting for covariates, CSF AB42, and CSF AB42*visit age. For both outcomes, individuals with greater global atrophy had worse performance. Lower hippocampal volumes were associated with greater age-related decline for learning (Model 4, Table 4). Regardless of age, lower hippocampal volumes were associated with lower recall (Model 3, Table 5). After adjusting for either neurodegeneration marker, CSF*visit age was significant for both RAVLT outcomes, with greater age-related declines for individuals with lower CSF AB42. Measures of global atrophy were associated with lower performance overall for both outcomes, whereas CSF AB42 and hippocampal volume were associated with greater decline on verbal learning. CSF AB42 and neurodegeneration interaction effects were non-significant; however, given the lower power for tests of higher-order interactions, caution is warranted. These results may suggest independent effects of these variables on verbal learning and memory performance in late middle-aged adults." @default.
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• W2897740922 date "2018-07-01" @default.
• W2897740922 modified "2023-10-16" @default.
• W2897740922 title "P3‐387: NEURODEGENERATION, AMYLOID, AND LONGITUDINAL VERBAL LEARNING AND MEMORY PERFORMANCE" @default.
• W2897740922 doi "https://doi.org/10.1016/j.jalz.2018.06.1749" @default.
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