Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897742366> ?p ?o ?g. }
- W2897742366 endingPage "36" @default.
- W2897742366 startingPage "26" @default.
- W2897742366 abstract "Neurons convey signals over long distances, for example motor neurons and sensory neurons project axons up to a meter long in humans. To this end, a sophisticated network of long-range signaling mechanisms enables communication between neuronal processes and somata. These mechanisms are activated during axonal injury and have essential roles both for sensing the injury and regulating subsequent regeneration. Here we survey the role of one such mechanism, axonal translation, which contributes to both retrograde injury signaling and as a source of proteins for regenerating axons. The nature of the axonal synthesis machinery has become progressively clearer over the past decade. A large number of axonally localized mRNAs have been identified, which cover a wide spectrum of protein families; and axonal ribosomes have been detected, even though their origin is still subject to debate. Various kinase pathways, most prominently mTOR, have been implicated in driving local translation in axons. Finally, new technologies are becoming available to visualize axonal translation and enable proteomic analyses. These technological improvements offer new avenues towards comprehensive characterization of the axonal translational machinery." @default.
- W2897742366 created "2018-10-26" @default.
- W2897742366 creator A5011348789 @default.
- W2897742366 creator A5065355117 @default.
- W2897742366 creator A5066395499 @default.
- W2897742366 creator A5068319322 @default.
- W2897742366 date "2019-02-01" @default.
- W2897742366 modified "2023-09-23" @default.
- W2897742366 title "Translating regeneration: Local protein synthesis in the neuronal injury response" @default.
- W2897742366 cites W1492116544 @default.
- W2897742366 cites W1499558552 @default.
- W2897742366 cites W1524308920 @default.
- W2897742366 cites W1535653900 @default.
- W2897742366 cites W1564741789 @default.
- W2897742366 cites W1578617720 @default.
- W2897742366 cites W1652058896 @default.
- W2897742366 cites W1678534475 @default.
- W2897742366 cites W1699411193 @default.
- W2897742366 cites W1731795725 @default.
- W2897742366 cites W1895042474 @default.
- W2897742366 cites W1910379468 @default.
- W2897742366 cites W1936157760 @default.
- W2897742366 cites W1946157893 @default.
- W2897742366 cites W1956327946 @default.
- W2897742366 cites W1967646152 @default.
- W2897742366 cites W1967946964 @default.
- W2897742366 cites W1970060945 @default.
- W2897742366 cites W1973561010 @default.
- W2897742366 cites W1976486184 @default.
- W2897742366 cites W1979312365 @default.
- W2897742366 cites W1979770213 @default.
- W2897742366 cites W1982190344 @default.
- W2897742366 cites W1984370169 @default.
- W2897742366 cites W1984447158 @default.
- W2897742366 cites W1985199742 @default.
- W2897742366 cites W1987935829 @default.
- W2897742366 cites W1992581871 @default.
- W2897742366 cites W1993534272 @default.
- W2897742366 cites W1994736346 @default.
- W2897742366 cites W1998965459 @default.
- W2897742366 cites W1999247220 @default.
- W2897742366 cites W2002226709 @default.
- W2897742366 cites W2003349524 @default.
- W2897742366 cites W2004285818 @default.
- W2897742366 cites W2004538934 @default.
- W2897742366 cites W2004661094 @default.
- W2897742366 cites W2006213039 @default.
- W2897742366 cites W2006257238 @default.
- W2897742366 cites W2010289572 @default.
- W2897742366 cites W2013865272 @default.
- W2897742366 cites W2014846478 @default.
- W2897742366 cites W2016943433 @default.
- W2897742366 cites W2018384224 @default.
- W2897742366 cites W2019873576 @default.
- W2897742366 cites W2020407536 @default.
- W2897742366 cites W2023110291 @default.
- W2897742366 cites W2023834045 @default.
- W2897742366 cites W2026117939 @default.
- W2897742366 cites W2027821655 @default.
- W2897742366 cites W2028585054 @default.
- W2897742366 cites W2029277937 @default.
- W2897742366 cites W2033056717 @default.
- W2897742366 cites W2035156666 @default.
- W2897742366 cites W2035396886 @default.
- W2897742366 cites W2036917322 @default.
- W2897742366 cites W2037313242 @default.
- W2897742366 cites W2038394514 @default.
- W2897742366 cites W2039086898 @default.
- W2897742366 cites W2040275406 @default.
- W2897742366 cites W2041675472 @default.
- W2897742366 cites W2044721985 @default.
- W2897742366 cites W2044931153 @default.
- W2897742366 cites W2045165874 @default.
- W2897742366 cites W2045546287 @default.
- W2897742366 cites W2048358400 @default.
- W2897742366 cites W2049474406 @default.
- W2897742366 cites W2050111488 @default.
- W2897742366 cites W2051118171 @default.
- W2897742366 cites W2062834772 @default.
- W2897742366 cites W2063704147 @default.
- W2897742366 cites W2067132969 @default.
- W2897742366 cites W2072552163 @default.
- W2897742366 cites W2073861762 @default.
- W2897742366 cites W2075189940 @default.
- W2897742366 cites W2076747046 @default.
- W2897742366 cites W2079838847 @default.
- W2897742366 cites W2080100938 @default.
- W2897742366 cites W2081578346 @default.
- W2897742366 cites W2082566454 @default.
- W2897742366 cites W2083252150 @default.
- W2897742366 cites W2088433724 @default.
- W2897742366 cites W2091285282 @default.
- W2897742366 cites W2091339773 @default.
- W2897742366 cites W2091597912 @default.
- W2897742366 cites W2093072982 @default.
- W2897742366 cites W2098439437 @default.
- W2897742366 cites W2102883851 @default.
- W2897742366 cites W2105989397 @default.