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- W2897743684 abstract "In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. However, we found an unanticipated effect of p53 loss in mouse and human G1-checkpoint-deficient cells: reduction of DNA damage. We show that abrogation of the G1/S-checkpoint allowed cells to enter S-phase under growth-restricting conditions at the expense of severe replication stress manifesting as decelerated DNA replication, reduced origin firing and accumulation of DNA double-strand breaks. In this system, loss of p53 allowed mitogen-independent proliferation, not by suppressing apoptosis, but rather by restoring origin firing and reducing DNA breakage. Loss of G1/S control also caused DNA damage and activation of p53 in an in vivo retinoblastoma model. Moreover, in a teratoma model, loss of p53 reduced DNA breakage. Thus, loss of p53 may promote growth of incipient cancer cells by reducing replication-stress-induced DNA damage." @default.
- W2897743684 created "2018-10-26" @default.
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- W2897743684 date "2018-10-16" @default.
- W2897743684 modified "2023-10-18" @default.
- W2897743684 title "Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells" @default.
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- W2897743684 doi "https://doi.org/10.7554/elife.37868" @default.
- W2897743684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6221544" @default.
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- W2897743684 hasPublicationYear "2018" @default.
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