Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897743688> ?p ?o ?g. }
- W2897743688 endingPage "87" @default.
- W2897743688 startingPage "73" @default.
- W2897743688 abstract "The association between subjective memory complaints (SMCs) and depressive symptoms has been widely reported and both have been regarded as risk factors for dementia, such as Alzheimer’s disease (AD). Although SMCs arise as early as in middle age, the exact neural correlates of comorbid depressive symptoms among individuals who are middle-aged and with SMCs have not yet been well investigated. Because rich-club organization of the brain plays a key role in the pathophysiology of various neuropsychiatric disorders, the investigation of rich club organization may provide insight regarding the neurobiological mechanisms of depressive symptoms in SMCs. In the current study, we compared the rich-club organization in the structural brain connectivity between individuals who have SMCs along with depressive symptoms (SMCD) and individuals with SMCs but without depressive symptoms (SMCO). A total of 53 individuals with SMCD and 91 individuals with SMCO participated in the study. For all participants, high-resolution, T1-weighted images and diffusion tensor images were obtained, and the network analysis was performed. Individuals with SMCD had lower connectivity strength between the precuneus and other rich-club nodes than those with SMCO, which was significant after adjusting for potential confounders. Our findings suggest that disruptions of rich-club connectivity strength of the precuenus are associated with depressive symptoms in middle-aged individuals with SMCs. Given that the precuneus is one of the commonly affected regions in the early stages of AD, our findings may imply that the concomitant depressive symptoms in middle-aged individuals with SMCs could reflect structural alterations related to AD." @default.
- W2897743688 created "2018-10-26" @default.
- W2897743688 creator A5021922923 @default.
- W2897743688 creator A5026755638 @default.
- W2897743688 creator A5031691743 @default.
- W2897743688 creator A5036277035 @default.
- W2897743688 creator A5052225742 @default.
- W2897743688 creator A5058291723 @default.
- W2897743688 creator A5059296853 @default.
- W2897743688 creator A5063257948 @default.
- W2897743688 creator A5065068590 @default.
- W2897743688 creator A5076081089 @default.
- W2897743688 creator A5077648174 @default.
- W2897743688 creator A5078674769 @default.
- W2897743688 creator A5084552968 @default.
- W2897743688 date "2018-10-08" @default.
- W2897743688 modified "2023-10-16" @default.
- W2897743688 title "Alterations in structural rich-club connectivity of the precuneus are associated with depressive symptoms among individuals with subjective memory complaints" @default.
- W2897743688 cites W129219452 @default.
- W2897743688 cites W132371621 @default.
- W2897743688 cites W1573278094 @default.
- W2897743688 cites W1584159866 @default.
- W2897743688 cites W1847412026 @default.
- W2897743688 cites W1910065219 @default.
- W2897743688 cites W1970129540 @default.
- W2897743688 cites W1972412818 @default.
- W2897743688 cites W1977481240 @default.
- W2897743688 cites W1980584599 @default.
- W2897743688 cites W1981656674 @default.
- W2897743688 cites W1982286843 @default.
- W2897743688 cites W1983475921 @default.
- W2897743688 cites W1984462107 @default.
- W2897743688 cites W1984624356 @default.
- W2897743688 cites W1984978256 @default.
- W2897743688 cites W1995608123 @default.
- W2897743688 cites W1997301424 @default.
- W2897743688 cites W1998633617 @default.
- W2897743688 cites W2008753452 @default.
- W2897743688 cites W2011877975 @default.
- W2897743688 cites W2012559638 @default.
- W2897743688 cites W2013485286 @default.
- W2897743688 cites W2023112642 @default.
- W2897743688 cites W2027156606 @default.
- W2897743688 cites W2030574287 @default.
- W2897743688 cites W2031686950 @default.
- W2897743688 cites W2032563801 @default.
- W2897743688 cites W2034142312 @default.
- W2897743688 cites W2037875344 @default.
- W2897743688 cites W2039364933 @default.
- W2897743688 cites W2042335287 @default.
- W2897743688 cites W2046250855 @default.
- W2897743688 cites W2047587201 @default.
- W2897743688 cites W2049840244 @default.
- W2897743688 cites W2051758041 @default.
- W2897743688 cites W2052318063 @default.
- W2897743688 cites W2053859325 @default.
- W2897743688 cites W2059637658 @default.
- W2897743688 cites W2060464767 @default.
- W2897743688 cites W2064955232 @default.
- W2897743688 cites W2065308899 @default.
- W2897743688 cites W2068717875 @default.
- W2897743688 cites W2069914240 @default.
- W2897743688 cites W2071869259 @default.
- W2897743688 cites W2074314670 @default.
- W2897743688 cites W2075496760 @default.
- W2897743688 cites W2075540078 @default.
- W2897743688 cites W2076143792 @default.
- W2897743688 cites W2084483696 @default.
- W2897743688 cites W2099083428 @default.
- W2897743688 cites W2101135654 @default.
- W2897743688 cites W2108024108 @default.
- W2897743688 cites W2108474398 @default.
- W2897743688 cites W2111613011 @default.
- W2897743688 cites W2112090702 @default.
- W2897743688 cites W2119190539 @default.
- W2897743688 cites W2119314215 @default.
- W2897743688 cites W2121031536 @default.
- W2897743688 cites W2121075052 @default.
- W2897743688 cites W2127591453 @default.
- W2897743688 cites W2129261325 @default.
- W2897743688 cites W2131055855 @default.
- W2897743688 cites W2134241741 @default.
- W2897743688 cites W2138790588 @default.
- W2897743688 cites W2139383541 @default.
- W2897743688 cites W2144138616 @default.
- W2897743688 cites W2145132952 @default.
- W2897743688 cites W2150111222 @default.
- W2897743688 cites W2155016044 @default.
- W2897743688 cites W2156151321 @default.
- W2897743688 cites W2158415185 @default.
- W2897743688 cites W2159929956 @default.
- W2897743688 cites W2161493176 @default.
- W2897743688 cites W2162551380 @default.
- W2897743688 cites W2162686834 @default.
- W2897743688 cites W2162724352 @default.
- W2897743688 cites W2163934375 @default.
- W2897743688 cites W2164638162 @default.
- W2897743688 cites W2167822639 @default.