FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897743803> ?p ?o ?g. }

• W2897743803 abstract "Abstract Bovine Salivary Protein 30b (BSP30b) is a member of the tubular lipid-binding (TULIP) superfamily that includes the human bactericidal/permeability-increasing proteins (BPI), lipopolysaccharide binding proteins (LBP) and palate, lung, and nasal epithelium carcinoma-21 associated proteins (PLUNC). BSP30b is most closely related to the PLUNC family and is predominantly found in bovine saliva. There are four BSP30 isoforms (BSP30a-d) and collectively, they are the most abundant protein component of bovine saliva. The PLUNC family members are proposed to be lipid binding proteins, although in most cases their lipid ligands are unknown. Here, we present the X-ray crystal structure of BSP30b at 2.0 Å resolution. We used a double methionine mutant and Se-Met SAD phasing to solve the structure. The structure adopts a curved cylindrical form with a hydrophobic channel formed by an α/β wrap, which is consistent with the TULIP superfamily. The structure of BSP30b in complex with oleic acid is also presented where the ligand is accommodated within the hydrophobic channel. The electron density for oleic acid suggests that the ligand is only partially occupied in the binding site implying that oleic acid may not be the preferred ligand. GFP-tagged BSP30b binds to the surface of olive oil droplets, as observed under fluorescent microscopy, and acts as a surfactant consistent with its association with decreased susceptibility to bloat in cattle. Bacteria extracted directly from bovine rumen contents indicate that the GFP_BSP30b fusion protein binds to a small number of selected bacterial species in vivo . These results suggest that BSP30b may bind to bacterial lipids from specific species and that this abundant protein may have important biological roles via interacting with rumen bacteria during feeding and rumination." @default.
• W2897743803 created "2018-10-26" @default.
• W2897743803 creator A5000685045 @default.
• W2897743803 creator A5004324173 @default.
• W2897743803 creator A5008353926 @default.
• W2897743803 creator A5019838895 @default.
• W2897743803 creator A5027997186 @default.
• W2897743803 creator A5034227844 @default.
• W2897743803 date "2018-10-19" @default.
• W2897743803 modified "2023-09-25" @default.
• W2897743803 title "The three dimensional structure of Bovine Salivary Protein 30b (BSP30b) and its interaction with specific rumen bacteria" @default.
• W2897743803 cites W1975110120 @default.
• W2897743803 cites W1975453286 @default.
• W2897743803 cites W1976421151 @default.
• W2897743803 cites W1983819887 @default.
• W2897743803 cites W1984191375 @default.
• W2897743803 cites W1989222475 @default.
• W2897743803 cites W1995098566 @default.
• W2897743803 cites W1999338090 @default.
• W2897743803 cites W2000225859 @default.
• W2897743803 cites W2001641653 @default.
• W2897743803 cites W2007747146 @default.
• W2897743803 cites W2014005588 @default.
• W2897743803 cites W2020242327 @default.
• W2897743803 cites W2022737873 @default.
• W2897743803 cites W2057741616 @default.
• W2897743803 cites W2060100629 @default.
• W2897743803 cites W2082268723 @default.
• W2897743803 cites W2082846873 @default.
• W2897743803 cites W2103714813 @default.
• W2897743803 cites W2109096072 @default.
• W2897743803 cites W2110035145 @default.
• W2897743803 cites W2110808180 @default.
• W2897743803 cites W2122189937 @default.
• W2897743803 cites W2127130852 @default.
• W2897743803 cites W2127538056 @default.
• W2897743803 cites W2139654449 @default.
• W2897743803 cites W2144081223 @default.
• W2897743803 cites W2163341755 @default.
• W2897743803 cites W2171364299 @default.
• W2897743803 cites W2224056471 @default.
• W2897743803 cites W2250472293 @default.
• W2897743803 doi "https://doi.org/10.1101/448167" @default.
• W2897743803 hasPublicationYear "2018" @default.
• W2897743803 type Work @default.
• W2897743803 sameAs 2897743803 @default.
• W2897743803 citedByCount "0" @default.
• W2897743803 crossrefType "posted-content" @default.
• W2897743803 hasAuthorship W2897743803A5000685045 @default.
• W2897743803 hasAuthorship W2897743803A5004324173 @default.
• W2897743803 hasAuthorship W2897743803A5008353926 @default.
• W2897743803 hasAuthorship W2897743803A5019838895 @default.
• W2897743803 hasAuthorship W2897743803A5027997186 @default.
• W2897743803 hasAuthorship W2897743803A5034227844 @default.
• W2897743803 hasBestOaLocation W28977438031 @default.
• W2897743803 hasConcept C100544194 @default.
• W2897743803 hasConcept C104317684 @default.
• W2897743803 hasConcept C116569031 @default.
• W2897743803 hasConcept C123894998 @default.
• W2897743803 hasConcept C142613039 @default.
• W2897743803 hasConcept C170493617 @default.
• W2897743803 hasConcept C185592680 @default.
• W2897743803 hasConcept C2781403372 @default.
• W2897743803 hasConcept C40767141 @default.
• W2897743803 hasConcept C504460877 @default.
• W2897743803 hasConcept C523546767 @default.
• W2897743803 hasConcept C54355233 @default.
• W2897743803 hasConcept C55493867 @default.
• W2897743803 hasConcept C70262065 @default.
• W2897743803 hasConcept C86803240 @default.
• W2897743803 hasConceptScore W2897743803C100544194 @default.
• W2897743803 hasConceptScore W2897743803C104317684 @default.
• W2897743803 hasConceptScore W2897743803C116569031 @default.
• W2897743803 hasConceptScore W2897743803C123894998 @default.
• W2897743803 hasConceptScore W2897743803C142613039 @default.
• W2897743803 hasConceptScore W2897743803C170493617 @default.
• W2897743803 hasConceptScore W2897743803C185592680 @default.
• W2897743803 hasConceptScore W2897743803C2781403372 @default.
• W2897743803 hasConceptScore W2897743803C40767141 @default.
• W2897743803 hasConceptScore W2897743803C504460877 @default.
• W2897743803 hasConceptScore W2897743803C523546767 @default.
• W2897743803 hasConceptScore W2897743803C54355233 @default.
• W2897743803 hasConceptScore W2897743803C55493867 @default.
• W2897743803 hasConceptScore W2897743803C70262065 @default.
• W2897743803 hasConceptScore W2897743803C86803240 @default.
• W2897743803 hasLocation W28977438031 @default.
• W2897743803 hasLocation W28977438032 @default.
• W2897743803 hasLocation W28977438033 @default.
• W2897743803 hasOpenAccess W2897743803 @default.
• W2897743803 hasPrimaryLocation W28977438031 @default.
• W2897743803 hasRelatedWork W1639439950 @default.
• W2897743803 hasRelatedWork W1789146931 @default.
• W2897743803 hasRelatedWork W2011178157 @default.
• W2897743803 hasRelatedWork W2082846877 @default.
• W2897743803 hasRelatedWork W2085712147 @default.
• W2897743803 hasRelatedWork W2100965180 @default.
• W2897743803 hasRelatedWork W2128504343 @default.
• W2897743803 hasRelatedWork W2897743803 @default.
• W2897743803 hasRelatedWork W2952987137 @default.
• W2897743803 hasRelatedWork W4235653293 @default.

• next