FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897746502> ?p ?o ?g. }

• W2897746502 abstract "Background and Purpose: Monitoring for hypotension, hyperglycemia, hypoxia, and dehydration is key to reducing early death in stroke patients. Evaluation of physiological predictors of infarct volume and mortality may provide opportunities for effective interventions to improve outcomes. The purpose of this study is: 1) to describe and compare the predictive effects of venous blood gas (VBG) on infarct volume and mortality in acute stroke in rats; 2) and we have begun to collect arterial blood gas (ABG) to compare differences obtained proximal and distal to the occluded intracranial thrombi in acute ischemic stroke patients. Methods: 3-month old Sprague-Dawey rats (n = 9) underwent permanent or transient middle cerebral artery occlusion (MCAO). Pre- and post-MCAO venous samples provided pH, pCO 2 , pO 2 , and electrolyte values (iCa 2+ , K + , and Na + ). Linear regression determined predictors of infarct volume from these values, and Cox regression analyzed VBG changes between tMCAO (n = 28) and pMCAO (n = 29) to determine predictors of mortality. We compared mean proximal and distal pH, pCO 2 , pO 2 , and electrolytes (iCa 2+ , K + , and Na + ) in stroke patients (n = 7) arterial samples using Wilcoxon Signed Ranks test. Results: Animal studies demonstrated pH and iCa 2+ are predictors of infarct volume, but not mortality. After pMCAO (n = 9), change in pH or iCa 2+ significantly predicted infarct volume [F(1,7) = 7.351, β = -0.716, p = 0.03] and [F(1, 7) = 6.782, β = -0.701, p = 0.035]; as pH and calcium decreased, infarct volume increased. These variables explained 44% and 42% of the total variance in these models. In human patients (n = 7), there were significant differences in blood samples proximal and distal to the intracranial thrombus for pCO 2 (p = 0.018), HCO 3- (p = 0.028), iCa 2+ (p = 0.043), K + (p = 0.028), and Na + (p = 0.044). Conclusions: In conclusion, there are acute changes in acid/base balance and electrolytes during stroke in rodent models and humans. In cross-species comparison ionized calcium changes were significant in both, with iCa 2+ changes predicting stroke volume in the rat model. These preliminary findings are novel, and warrant further exploration in human patients." @default.
• W2897746502 created "2018-10-26" @default.
• W2897746502 creator A5003316044 @default.
• W2897746502 creator A5004542046 @default.
• W2897746502 creator A5018746613 @default.
• W2897746502 creator A5027536474 @default.
• W2897746502 creator A5037596507 @default.
• W2897746502 creator A5054216857 @default.
• W2897746502 creator A5074080359 @default.
• W2897746502 date "2018-01-22" @default.
• W2897746502 modified "2023-09-23" @default.
• W2897746502 title "Abstract WMP113: Translational Evaluation of Acid/Base and Electrolyte Alterations in Acute Large Vessel Stroke" @default.
• W2897746502 doi "https://doi.org/10.1161/str.49.suppl_1.wmp113" @default.
• W2897746502 hasPublicationYear "2018" @default.
• W2897746502 type Work @default.
• W2897746502 sameAs 2897746502 @default.
• W2897746502 citedByCount "0" @default.
• W2897746502 crossrefType "journal-article" @default.
• W2897746502 hasAuthorship W2897746502A5003316044 @default.
• W2897746502 hasAuthorship W2897746502A5004542046 @default.
• W2897746502 hasAuthorship W2897746502A5018746613 @default.
• W2897746502 hasAuthorship W2897746502A5027536474 @default.
• W2897746502 hasAuthorship W2897746502A5037596507 @default.
• W2897746502 hasAuthorship W2897746502A5054216857 @default.
• W2897746502 hasAuthorship W2897746502A5074080359 @default.
• W2897746502 hasConcept C126322002 @default.
• W2897746502 hasConcept C127413603 @default.
• W2897746502 hasConcept C147789679 @default.
• W2897746502 hasConcept C164705383 @default.
• W2897746502 hasConcept C17525397 @default.
• W2897746502 hasConcept C185592680 @default.
• W2897746502 hasConcept C2776572282 @default.
• W2897746502 hasConcept C2780645631 @default.
• W2897746502 hasConcept C3020166492 @default.
• W2897746502 hasConcept C68801617 @default.
• W2897746502 hasConcept C71924100 @default.
• W2897746502 hasConcept C78519656 @default.
• W2897746502 hasConceptScore W2897746502C126322002 @default.
• W2897746502 hasConceptScore W2897746502C127413603 @default.
• W2897746502 hasConceptScore W2897746502C147789679 @default.
• W2897746502 hasConceptScore W2897746502C164705383 @default.
• W2897746502 hasConceptScore W2897746502C17525397 @default.
• W2897746502 hasConceptScore W2897746502C185592680 @default.
• W2897746502 hasConceptScore W2897746502C2776572282 @default.
• W2897746502 hasConceptScore W2897746502C2780645631 @default.
• W2897746502 hasConceptScore W2897746502C3020166492 @default.
• W2897746502 hasConceptScore W2897746502C68801617 @default.
• W2897746502 hasConceptScore W2897746502C71924100 @default.
• W2897746502 hasConceptScore W2897746502C78519656 @default.
• W2897746502 hasIssue "Suppl_1" @default.
• W2897746502 hasLocation W28977465021 @default.
• W2897746502 hasOpenAccess W2897746502 @default.
• W2897746502 hasPrimaryLocation W28977465021 @default.
• W2897746502 hasRelatedWork W2914317231 @default.
• W2897746502 hasRelatedWork W2914961095 @default.
• W2897746502 hasRelatedWork W2961752373 @default.
• W2897746502 hasRelatedWork W3176794935 @default.
• W2897746502 hasVolume "49" @default.
• W2897746502 isParatext "false" @default.
• W2897746502 isRetracted "false" @default.
• W2897746502 magId "2897746502" @default.
• W2897746502 workType "article" @default.