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- W2897746650 endingPage "556" @default.
- W2897746650 startingPage "544" @default.
- W2897746650 abstract "Impaired mitochondrial function and activation of NLRP3 inflammasome cascade has a significant role in the pathogenesis of myocardial ischemia–reperfusion (IR) injury. The current study investigated whether eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or their corresponding CYP epoxygenase metabolites 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP) protect against IR injury. Isolated mouse hearts were perfused in the Langendorff mode with vehicle, DHA, 19,20-EDP, EPA, or 17,18-EEQ and subjected to 30 min of ischemia and followed by 40 min of reperfusion. In contrast with EPA and 17,18-EEQ, DHA and 19,20-EDP exerted cardioprotection, as shown by a significant improvement in postischemic functional recovery associated with significant attenuation of NLRP3 inflammasome complex activation and preserved mitochondrial function. Hearts perfused with DHA or 19,20-EDP displayed a marked reduction in localization of mitochondrial Drp-1 and Mfn-2 as well as maintained Opa-1 levels. DHA and 19,20-EDP preserved the activities of both the cytosolic Trx-1 and mitochondrial Trx-2. DHA cardioprotective effect was attenuated by the CYP epoxygenase inhibitor N-(methysulfonyl)-2-(2-propynyloxy)-benzenehexanamide. In conclusion, our data indicate a differential cardioprotective response between DHA, EPA, and their active metabolites toward IR injury. Interestingly, 19,20-EDP provided the best protection against IR injury via maintaining mitochondrial function and thereby reducing the detrimental NLRP3 inflammasome responses." @default.
- W2897746650 created "2018-10-26" @default.
- W2897746650 creator A5018267752 @default.
- W2897746650 creator A5027606939 @default.
- W2897746650 creator A5030065842 @default.
- W2897746650 creator A5034026354 @default.
- W2897746650 creator A5036367392 @default.
- W2897746650 date "2019-06-01" @default.
- W2897746650 modified "2023-10-14" @default.
- W2897746650 title "Cardioprotective effects of CYP-derived epoxy metabolites of docosahexaenoic acid involve limiting NLRP3 inflammasome activation" @default.
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- W2897746650 doi "https://doi.org/10.1139/cjpp-2018-0480" @default.
- W2897746650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30326194" @default.
- W2897746650 hasPublicationYear "2019" @default.
- W2897746650 type Work @default.