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- W2897746669 abstract "In this study, we examine a means for developing near-IR fluorescent sensors through streamlined, site-specific coupling with peptide-based receptors. As the penultimate step of solid-phase synthesis of a peptide-based receptor, we show a simple means of labeling the N' terminus with the near IR fluorophore IR-783 to afford a viable fluorescent sensor after cleavage from the resin. The proof-of-concept probe utilized a biotin mimetic peptide sequence as the receptive moiety. Here we revealed a turn-on fluorescence enhancement upon binding of the biotin mimetic probe to its intended streptavidin target. Not all peptide-receptive moieties tested were able to generate such an enhancement upon target binding, and as such, the rationale for the observed fluorescence response properties is discussed." @default.
- W2897746669 created "2018-10-26" @default.
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- W2897746669 date "2018-10-16" @default.
- W2897746669 modified "2023-10-02" @default.
- W2897746669 title "IR-783 Labeling of a Peptide Receptor for ‘Turn-On’ Fluorescence Based Sensing" @default.
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- W2897746669 doi "https://doi.org/10.3390/chemosensors6040047" @default.
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