Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897746699> ?p ?o ?g. }
- W2897746699 endingPage "293" @default.
- W2897746699 startingPage "278" @default.
- W2897746699 abstract "Over the last decade, the term process intensification (PI) has been applied almost exclusively to large scale chemical processes, but hardly to aspects of biopharmaceutical manufacturing, and not at all to relatively small scale, but high value generating pharmaceutical productions. Personalized and stratified medicine approaches for innovative therapies are changing that as well as economic limitations for health care systems in ageing society. Recent developments have resulted in new concepts for biologics manufacturing. The chemical engineering tool box for the adoption of process intensification methods to biologics is ready for industrial transfer; e.g. process modelling and comprehension, miniaturization/ scaled-down equipment for rapid process development, advanced process control, innovative analytics, mass transfer enhancement and process integration. Nevertheless, methods and equipment of process intensification, developed for chemical engineering applications, which are not as strictly regulated as in the case of biologics manufacturing, cannot simply be transferred to biotherapeutical applications. They require specific adjustment to the technological and regulatory requirements, for example any process intensification step within process development has to be finalized before producing first supplies for clinical trials. This generates quite a challenge with regard to technical readiness level and organization of companies in process development and implementation." @default.
- W2897746699 created "2018-10-26" @default.
- W2897746699 creator A5010013198 @default.
- W2897746699 creator A5022027983 @default.
- W2897746699 creator A5044900422 @default.
- W2897746699 creator A5051418330 @default.
- W2897746699 creator A5062349201 @default.
- W2897746699 creator A5085531224 @default.
- W2897746699 creator A5088877326 @default.
- W2897746699 date "2018-11-01" @default.
- W2897746699 modified "2023-10-08" @default.
- W2897746699 title "Process intensification in biologics manufacturing" @default.
- W2897746699 cites W144079886 @default.
- W2897746699 cites W1513115519 @default.
- W2897746699 cites W1527359793 @default.
- W2897746699 cites W1546823599 @default.
- W2897746699 cites W1965386178 @default.
- W2897746699 cites W1966439449 @default.
- W2897746699 cites W1970086692 @default.
- W2897746699 cites W1970709541 @default.
- W2897746699 cites W1974770311 @default.
- W2897746699 cites W1978818708 @default.
- W2897746699 cites W1986974221 @default.
- W2897746699 cites W1990864380 @default.
- W2897746699 cites W1991251540 @default.
- W2897746699 cites W1993598516 @default.
- W2897746699 cites W1993899478 @default.
- W2897746699 cites W1994179017 @default.
- W2897746699 cites W1994413319 @default.
- W2897746699 cites W1998198411 @default.
- W2897746699 cites W2000933561 @default.
- W2897746699 cites W2004721062 @default.
- W2897746699 cites W2005032091 @default.
- W2897746699 cites W2008208385 @default.
- W2897746699 cites W2011777786 @default.
- W2897746699 cites W2011842198 @default.
- W2897746699 cites W2012987661 @default.
- W2897746699 cites W2014968314 @default.
- W2897746699 cites W2017646143 @default.
- W2897746699 cites W2020667406 @default.
- W2897746699 cites W2020980946 @default.
- W2897746699 cites W2021076065 @default.
- W2897746699 cites W2021443819 @default.
- W2897746699 cites W2022072246 @default.
- W2897746699 cites W2022249090 @default.
- W2897746699 cites W2028836771 @default.
- W2897746699 cites W2029046920 @default.
- W2897746699 cites W2030685682 @default.
- W2897746699 cites W2031594702 @default.
- W2897746699 cites W2033980728 @default.
- W2897746699 cites W2039886914 @default.
- W2897746699 cites W2042379506 @default.
- W2897746699 cites W2043741386 @default.
- W2897746699 cites W2045662395 @default.
- W2897746699 cites W2051325383 @default.
- W2897746699 cites W2053538701 @default.
- W2897746699 cites W2053632726 @default.
- W2897746699 cites W2053789977 @default.
- W2897746699 cites W2058107875 @default.
- W2897746699 cites W2059524887 @default.
- W2897746699 cites W2071524959 @default.
- W2897746699 cites W2072311820 @default.
- W2897746699 cites W2072944401 @default.
- W2897746699 cites W2075802407 @default.
- W2897746699 cites W2077157615 @default.
- W2897746699 cites W2078453041 @default.
- W2897746699 cites W2078551883 @default.
- W2897746699 cites W2079753636 @default.
- W2897746699 cites W2082059792 @default.
- W2897746699 cites W2082568784 @default.
- W2897746699 cites W2082987894 @default.
- W2897746699 cites W2084043161 @default.
- W2897746699 cites W2084142669 @default.
- W2897746699 cites W2086844465 @default.
- W2897746699 cites W2087246800 @default.
- W2897746699 cites W2089036989 @default.
- W2897746699 cites W2092882874 @default.
- W2897746699 cites W2094979322 @default.
- W2897746699 cites W2095596891 @default.
- W2897746699 cites W2100508150 @default.
- W2897746699 cites W2102791608 @default.
- W2897746699 cites W2107085081 @default.
- W2897746699 cites W2107885958 @default.
- W2897746699 cites W2118540273 @default.
- W2897746699 cites W2118634197 @default.
- W2897746699 cites W2118694083 @default.
- W2897746699 cites W2131774841 @default.
- W2897746699 cites W2134192699 @default.
- W2897746699 cites W2144382621 @default.
- W2897746699 cites W2151618927 @default.
- W2897746699 cites W2158615615 @default.
- W2897746699 cites W2163522818 @default.
- W2897746699 cites W2165047551 @default.
- W2897746699 cites W2168338758 @default.
- W2897746699 cites W2169620403 @default.
- W2897746699 cites W2170146374 @default.
- W2897746699 cites W2207448650 @default.
- W2897746699 cites W2231331860 @default.