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• W2897746919 abstract "INTRODUCTION:Neuromuscular blocking agents are commonly used to facilitate tracheal intubation.An ideal muscle relaxant should have rapid onset, profound relaxation of all muscles and short duration of action so that the patient’s own respiratory function can be restored, should intubation proved to be impossible.These requirements are best met with Succinylcholine, an ultra-short acting depolarizing muscle relaxant. Unfortunately, succinylcholine has many undesirable side effects, some of which may be life threatening.Rocuronium bromide is a newer steroidal non-depolarizing neuromuscular blocker with a rapid onset and may be a suitable alternative to succinylcholine for rapid control of airway.There is dose dependent decrease in onset time with Rocuronium and dose of Rocuronium used may influence the rate of onset of satisfactory intubating conditions.Large doses of Rocuronium (more than 1mg/kg) produces ideal intubating conditions in 30-60 seconds but the duration of action is very much prolonged.AIM OF THE STUDY:The aim of my study is to evaluate the intubating conditions in 60 seconds using two different doses of Rocuronium with suxamethonium for intubation in children.It is a study comparing two doses of Rocuronium (0.6mg/kg (2xED95) and 0.9mg/kg (3xED95) with suxamethonium 1.5mg/kg for intubation in children in 60 seconds and observed:1) Intubating conditions,2) Hemodynamic changes,3) Adverse effects.MATERIALS AND METHODS:This study was conducted at Government Stanley Medical College and Hospital, Chennai.After institutional approval and informed consent, 60 patients were enrolled in the study.Inclusion Criteria:1. Children between 2 – 10 years,2. ASA Physical status I & II,3. For Elective surgeries posted under G.A.Exclusion Criteria:1. Infants.2. Known / suspected difficult Intubation.3. H/o any neuromuscular disorder.4. Renal / Hepatic disorder.5. Known allergy to drugs.6. Surgical procedures of very short duration.7. Patients receiving any medication known to interact with Neuromuscular blocking agent.STATISTICAL ANALYSIS:The data was computed and all values were expressed as mean +SD. The data was analysed using one way anova test, unpaired t test, chi-square test, mann-whitney u test, and kruskal wallis test as appropriate.SUMMARY:1) Both doses of Rocuronium 0.6mg/kg and 0.9mg/kg produced acceptable intubatingconditions (good or excellent) in one minute.2) But, Excellent intubating conditions identical to suxamethonium was provided withrocuronium 0.9mg/kg group.3) Duration of action was significantly more in Rocuronium 0.9mg/kg group when compared to suxamethonium.4) No signs of Histamine release was observed in any of the patients.5) Increase in Heart rate and Blood pressure at intubation was more in Rocuronium 0.6mg/kg group compared to other groups.CONCLUSION:Rocuronium 0.9mg/kg (3xED95) can be used as an alternative ideal agent to suxamethonium for intubation in children. But while choosing Rocuronium as an alternative to suxamethonium factors such as intubation difficulty and surgical duration should be considered against the potential side effects of suxamethonium." @default.
• W2897746919 created "2018-10-26" @default.
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• W2897746919 date "2006-02-01" @default.
• W2897746919 modified "2023-09-24" @default.
• W2897746919 title "A Study Comparing Two Doses of Rocuronium [(0.6 mg/kg (2xED95) and 0.9mg/kg (3xED95)] with Suxamethonium (1.5mg/kg) for Intubation in Children in 60 seconds" @default.
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