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• W2897748603 abstract "Salivary duct carcinoma (SDC) is a rare and aggressive malignancy for which limited data exist to guide treatment decisions. With the advent of advanced molecular testing and tumor genomic profiling, clinicians now have the ability to identify potential therapeutic targets in difficult-to-treat cancers such as SDC. This report presents a male patient with widely metastatic SDC found on targeted next-generation sequencing to have a BRAF p.V600E mutation. He experienced a prolonged and robust response to first-line systemic chemotherapy with dabrafenib and trametinib. During his response interval, new data emerged to justify subsequent treatment with both an immune checkpoint inhibitor and androgen blockade after his disease progressed. To our knowledge, this is the first report of frontline BRAF-directed therapy eliciting a response in metastatic SDC." @default.
• W2897748603 created "2018-10-26" @default.
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• W2897748603 date "2018-10-01" @default.
• W2897748603 modified "2023-09-26" @default.
• W2897748603 title "First-Line Treatment of Widely Metastatic <i>BRAF</i>-Mutated Salivary Duct Carcinoma With Combined BRAF and MEK Inhibition" @default.
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• W2897748603 doi "https://doi.org/10.6004/jnccn.2018.7056" @default.
• W2897748603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6292446" @default.
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• W2897748603 hasPublicationYear "2018" @default.
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