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• W2897749710 abstract "To evaluate the differences in the treatment related toxicity and neutropenia rate between patients with nasopharyngeal cancer treated by IMPT and VMAT. From December 2016 to December 2017, 27 patients receiving IMPT and 54 patients receiving VMAT for nasopharyngeal caner were propensity score-matched with 1:2 ratio. The propensity score were generated based on age, sex, T-stage, N-stage, EBV status and treatment modalities. The National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE 4.03) was used for toxicity evaluation. Chi-square test was used in the univariate analysis. Then multivariate logistic regression analysis was used in the multivariate analysis for binary toxicity endpoints. The median follow-up time was eight months. There were no imbalances between the two cohorts patients. During treatment, 6 IMPT-treated patients (22.2%) and 27 VMAT-treated patients (50%) were suffered from nasogastric tube insertion or weight loss over 8 % from baseline (OR=0.286, P=0.018). Two patients (7.4%) in IMPT cohort and eight patients(14.8%) in VMAT cohort required NG-tube insertion. The mean duration of NG-tube placement was 2 and 6.4 weeks in the IMPT and VMAT patients respectively (P=0.318). Of the patients treating with concurrent chemoradiotherapy, there were significantly less neutropenia adverse events in IMPT group compared with VMAT group (OR=0.324, P=0.029). There were only one patient (4.2%) in IMPT group and seven patients (14.3%) in VMAT group not receiving cisplatin dose intensity over 200 mg/m2. After allowing potential confounders in multivariate analysis, IMPT treatment retained its independent association with NG-tube insertion or weight loss over 8% (P=0.049)and neutropenia adverse events (P=0.039). IMPT is associated with reduced rates of NG-tube insertion or weight loss over 8% and neutropenia adverse events. The result may potentially increase treatment outcome for nasopharyngeal cancer patients treated with IMPT. Abstract MO_10_2554; Table 1IMPT (N =27)VMAT (N=54)OR (95% CI)P valueNG tube during treatment, No. (%)2 (7.4)8 (14.8)0.460 (0.091-2.334)0.483NG tube duration, mean (IQR), wks6.4 (4.5-8.3)2 (1-3)0.318Weight loss over 8%, No. (%)5 (18.5)22 (40.7)0.331 (0.109-1.006)0.051Weight loss over 8% or NG tube during treatment, No. (%)6 (22.2)27 (50.0)0.286 (0.100-0.819)0.018Total cisplatin dose < 200mg/m21 (4.2)7 (14.3)0.261 (0.030-2.253)0.258Neutropenia any grade12 (50.0)37 (75.5)0.324 (0.116-0.910)0.029Emergency Room Visit3 (11.1)8 (14.8)0.719 (0.174-2.961)0.744 Open table in a new tab" @default.
• W2897749710 created "2018-10-26" @default.
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• W2897749710 date "2018-11-01" @default.
• W2897749710 modified "2023-10-17" @default.
• W2897749710 title "Intensity-Modulated Proton Therapy Reduces Acute Treatment-Related Toxicities for Patients with Nasopharyngeal Cancer: A Case-Control Propensity Score Match Study with Volumetric Modulated Arc Therapy" @default.
• W2897749710 doi "https://doi.org/10.1016/j.ijrobp.2018.07.797" @default.
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