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- W2897750229 abstract "Abstract The management of locally advanced esophageal cancer remains complex and necessitates a multimodality approach in order to achieve favorable survival outcomes. Given the evidence to date, several generalizations regarding effective local and systemic treatment strategies can be drawn. With respect to local control, excellent surgery remains paramount as evidenced by improved outcomes associated with R0 resection. En bloc esophagectomy has been shown to provide excellent results, and its impact with respect to survival in large randomized trials is currently under elucidation in the NeXT, TOP GEAR, and Neo AEGIS trials. The inability to achieve R0 resection in a significant proportion of patients mandates additional local therapy. For patients with squamous cell carcinoma, neoadjuvant chemoradiotherapy (CRT) provides excellent results and represents standard therapy. With respect to patients with esophageal adenocarcinoma, the benefit of neoadjuvant CRT is less pronounced but remains an acceptable standard. Excellent results have been reported with docetaxel-based triplets, which appear to be borne out in contemporary meta-analysis. Accordingly, neoadjuvant chemotherapy alone remains an acceptable standard in this patient population. In the present chapter, the literature to date is extensively reviewed, and the up-to-date standardized treatment strategies are outlined." @default.
- W2897750229 created "2018-10-26" @default.
- W2897750229 creator A5037501509 @default.
- W2897750229 creator A5044048665 @default.
- W2897750229 date "2019-01-01" @default.
- W2897750229 modified "2023-09-23" @default.
- W2897750229 title "Multimodality Therapy in the Management of Locally Advanced Esophageal Cancer" @default.
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- W2897750229 doi "https://doi.org/10.1016/b978-0-323-40232-3.00038-8" @default.
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