Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897760082> ?p ?o ?g. }
- W2897760082 endingPage "638" @default.
- W2897760082 startingPage "632" @default.
- W2897760082 abstract "For a number of mental health disorders, including posttraumatic stress disorders (PTSD), there are not many available treatment options. Recently, there has been renewed interest in the potential of methylenedioxymethamphetamine (MDMA) to restore function for patients with these disorders. The primary hypothesis is that MDMA, via prosocial effects, increases the ability of patients to address the underlying psychopathology of the disorder. However, the use of MDMA poses potential problems of neurotoxicity, in addition to its own potential for misuse.In this article, the proposed potential of MDMA as an adjunct to psychotherapy for PTSD is evaluated. The rationale for the use of MDMA and the positive results of studies that have administered MDMA in the treatment of PTSD are provided (pros). A description of potential adverse effects of treatment is also presented (cons). An overview of MDMA pharmacology and pharmacokinetics and a description of potential adverse effects of treatments are also presented. Methylenedioxymethamphetamine-produced oxytocin release and decreased expression of fear conditioning as well as one of the MDMA enantiomers (the n R- entaniomer) are suggested as potential mechanisms for the beneficial effects of MDMA in PTSD (suggestions).There is some evidence that MDMA facilitates recovery of PTSD. However, the significant adverse effects of MDMA raise concern for its adoption as a pharmacotherapy. Alternative potential treatments with less adverse effects and that are based on the ubiquitous pharmacology of MDMA are presented.We suggest that additional research investigating the basis for the putative beneficial effects of MDMA might reveal an effective treatment with fewer adverse effects. Suggestions of alternative treatments based on the behavioral pharmacology and toxicology of MDMA and its enantiomers are presented." @default.
- W2897760082 created "2018-10-26" @default.
- W2897760082 creator A5006357330 @default.
- W2897760082 creator A5080398922 @default.
- W2897760082 date "2018-12-01" @default.
- W2897760082 modified "2023-10-15" @default.
- W2897760082 title "Methylenedioxymethamphetamine (MDMA) in Psychiatry" @default.
- W2897760082 cites W120429996 @default.
- W2897760082 cites W1479855792 @default.
- W2897760082 cites W1487335348 @default.
- W2897760082 cites W1494251237 @default.
- W2897760082 cites W1514792206 @default.
- W2897760082 cites W1517515257 @default.
- W2897760082 cites W1547865271 @default.
- W2897760082 cites W1588615075 @default.
- W2897760082 cites W1750764127 @default.
- W2897760082 cites W1810864195 @default.
- W2897760082 cites W1880731034 @default.
- W2897760082 cites W1902335676 @default.
- W2897760082 cites W1919106491 @default.
- W2897760082 cites W1966544510 @default.
- W2897760082 cites W1967791661 @default.
- W2897760082 cites W1971746914 @default.
- W2897760082 cites W1971769956 @default.
- W2897760082 cites W1976834001 @default.
- W2897760082 cites W1981410800 @default.
- W2897760082 cites W1983947475 @default.
- W2897760082 cites W1986219496 @default.
- W2897760082 cites W1986562224 @default.
- W2897760082 cites W1987505756 @default.
- W2897760082 cites W1990140024 @default.
- W2897760082 cites W1991718370 @default.
- W2897760082 cites W1993845390 @default.
- W2897760082 cites W1997306238 @default.
- W2897760082 cites W1999030266 @default.
- W2897760082 cites W1999143702 @default.
- W2897760082 cites W1999159677 @default.
- W2897760082 cites W1999266594 @default.
- W2897760082 cites W2001794597 @default.
- W2897760082 cites W2001819272 @default.
- W2897760082 cites W2002969394 @default.
- W2897760082 cites W2003616879 @default.
- W2897760082 cites W2003984864 @default.
- W2897760082 cites W2011248808 @default.
- W2897760082 cites W2011428797 @default.
- W2897760082 cites W2012633810 @default.
- W2897760082 cites W2015928428 @default.
- W2897760082 cites W2024901368 @default.
- W2897760082 cites W2025216803 @default.
- W2897760082 cites W2025797117 @default.
- W2897760082 cites W2026836897 @default.
- W2897760082 cites W2033577954 @default.
- W2897760082 cites W2036507295 @default.
- W2897760082 cites W2039714243 @default.
- W2897760082 cites W2040246552 @default.
- W2897760082 cites W2040402447 @default.
- W2897760082 cites W2040452225 @default.
- W2897760082 cites W2041614065 @default.
- W2897760082 cites W2042007776 @default.
- W2897760082 cites W2042847262 @default.
- W2897760082 cites W2043934883 @default.
- W2897760082 cites W2045098693 @default.
- W2897760082 cites W2046759010 @default.
- W2897760082 cites W2048841731 @default.
- W2897760082 cites W2051226001 @default.
- W2897760082 cites W2052323109 @default.
- W2897760082 cites W2056429846 @default.
- W2897760082 cites W2061996774 @default.
- W2897760082 cites W2064135174 @default.
- W2897760082 cites W2066189612 @default.
- W2897760082 cites W2069625646 @default.
- W2897760082 cites W2071107645 @default.
- W2897760082 cites W2073293352 @default.
- W2897760082 cites W2073377994 @default.
- W2897760082 cites W2073927880 @default.
- W2897760082 cites W2075104053 @default.
- W2897760082 cites W2075552167 @default.
- W2897760082 cites W2080017984 @default.
- W2897760082 cites W2083114671 @default.
- W2897760082 cites W2084385783 @default.
- W2897760082 cites W2086190854 @default.
- W2897760082 cites W2089149909 @default.
- W2897760082 cites W2093943230 @default.
- W2897760082 cites W2095188030 @default.
- W2897760082 cites W2096693006 @default.
- W2897760082 cites W2097563002 @default.
- W2897760082 cites W2103339553 @default.
- W2897760082 cites W2105541798 @default.
- W2897760082 cites W2106141951 @default.
- W2897760082 cites W2107526208 @default.
- W2897760082 cites W2109121812 @default.
- W2897760082 cites W2109647938 @default.
- W2897760082 cites W2109698385 @default.
- W2897760082 cites W2110701839 @default.
- W2897760082 cites W2113485684 @default.
- W2897760082 cites W2114183716 @default.
- W2897760082 cites W2116536917 @default.
- W2897760082 cites W2116910569 @default.