FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897760136> ?p ?o ?g. }

• W2897760136 endingPage "e508" @default.
• W2897760136 startingPage "e508" @default.
• W2897760136 abstract "To elucidate the immunomodulatory effects of dimethyl fumarate (DMF) on B cells in patients with relapsing MS receiving DMF as a 1st-line vs 2nd-line therapy.B cells were isolated from 43 patients with MS at baseline and after 15-week DMF therapy. Phenotype and functional markers and cytokine profile were assessed by flow cytometry. Analysis included clinical and MRI parameters recorded during a 1-year follow-up.1st-line and 2nd-line patients presented several differences in their baseline immune profile, which corresponded with differences in their immunologic response to DMF treatment. DMF reduced the proportions of B cells and CD8 T cells whereas increased monocytes. DMF reduced memory B cells, including plasma cells in 2nd-line patients only, whereas strongly increased transitional B cells. Several IL10+ B-cell subsets and TGFβ+ B cells were increased. Proinflammatory LTα+ and TNFα+ B cells were reduced, while IL4+ B cells elevated, whereas IFNγ+ B cells showed opposite effects in 1st-line and 2nd-line patients. HLA and ICAM-1 expression was increased, but % CD86+ B cells reduced. The expression of B-cell activating factor receptor and the proportion of activated CD69 B cells were increased.DMF is associated with increased transitional and IL10+ and TGFβ+ regulatory B cells and a shift toward a more anti-inflammatory immune profile. Cell activation with reduced costimulatory capacity may induce immune hyporesponsiveness. Carryover effects of preceding therapies in 2nd-line patients and the stage of disease influence the immune profile of the patients and the immunomodulatory effects of DMF." @default.
• W2897760136 created "2018-10-26" @default.
• W2897760136 creator A5009284606 @default.
• W2897760136 creator A5028777119 @default.
• W2897760136 creator A5066918274 @default.
• W2897760136 creator A5083168810 @default.
• W2897760136 date "2018-10-16" @default.
• W2897760136 modified "2023-10-18" @default.
• W2897760136 title "Dimethyl fumarate as a first- vs second-line therapy in MS" @default.
• W2897760136 cites W1503016118 @default.
• W2897760136 cites W1565993808 @default.
• W2897760136 cites W1816536644 @default.
• W2897760136 cites W1963701987 @default.
• W2897760136 cites W1967838438 @default.
• W2897760136 cites W1978094617 @default.
• W2897760136 cites W1981621288 @default.
• W2897760136 cites W1985038762 @default.
• W2897760136 cites W1999749077 @default.
• W2897760136 cites W2004804582 @default.
• W2897760136 cites W2006236831 @default.
• W2897760136 cites W2011644457 @default.
• W2897760136 cites W2020206181 @default.
• W2897760136 cites W2022648902 @default.
• W2897760136 cites W2027129171 @default.
• W2897760136 cites W2046128399 @default.
• W2897760136 cites W2054226526 @default.
• W2897760136 cites W2056209646 @default.
• W2897760136 cites W2061806673 @default.
• W2897760136 cites W2067701958 @default.
• W2897760136 cites W2086080135 @default.
• W2897760136 cites W2088328410 @default.
• W2897760136 cites W2093009907 @default.
• W2897760136 cites W2099443640 @default.
• W2897760136 cites W2113291839 @default.
• W2897760136 cites W2122545833 @default.
• W2897760136 cites W2140999266 @default.
• W2897760136 cites W2141111992 @default.
• W2897760136 cites W2142577589 @default.
• W2897760136 cites W2153193872 @default.
• W2897760136 cites W2153242844 @default.
• W2897760136 cites W2288282768 @default.
• W2897760136 cites W2300277733 @default.
• W2897760136 cites W2314741982 @default.
• W2897760136 cites W2328593359 @default.
• W2897760136 cites W2344296295 @default.
• W2897760136 cites W2577405982 @default.
• W2897760136 cites W2597919924 @default.
• W2897760136 cites W2606862055 @default.
• W2897760136 cites W2609542724 @default.
• W2897760136 doi "https://doi.org/10.1212/nxi.0000000000000508" @default.
• W2897760136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192691" @default.
• W2897760136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30345334" @default.
• W2897760136 hasPublicationYear "2018" @default.
• W2897760136 type Work @default.
• W2897760136 sameAs 2897760136 @default.
• W2897760136 citedByCount "10" @default.
• W2897760136 countsByYear W28977601362019 @default.
• W2897760136 countsByYear W28977601362020 @default.
• W2897760136 countsByYear W28977601362022 @default.
• W2897760136 countsByYear W28977601362023 @default.
• W2897760136 crossrefType "journal-article" @default.
• W2897760136 hasAuthorship W2897760136A5009284606 @default.
• W2897760136 hasAuthorship W2897760136A5028777119 @default.
• W2897760136 hasAuthorship W2897760136A5066918274 @default.
• W2897760136 hasAuthorship W2897760136A5083168810 @default.
• W2897760136 hasBestOaLocation W28977601361 @default.
• W2897760136 hasConcept C126322002 @default.
• W2897760136 hasConcept C153911025 @default.
• W2897760136 hasConcept C159654299 @default.
• W2897760136 hasConcept C167672396 @default.
• W2897760136 hasConcept C203014093 @default.
• W2897760136 hasConcept C2776090121 @default.
• W2897760136 hasConcept C2776819417 @default.
• W2897760136 hasConcept C2778453870 @default.
• W2897760136 hasConcept C2778690821 @default.
• W2897760136 hasConcept C2780640218 @default.
• W2897760136 hasConcept C2781101188 @default.
• W2897760136 hasConcept C54355233 @default.
• W2897760136 hasConcept C553184892 @default.
• W2897760136 hasConcept C71924100 @default.
• W2897760136 hasConcept C81885089 @default.
• W2897760136 hasConcept C86803240 @default.
• W2897760136 hasConcept C8891405 @default.
• W2897760136 hasConceptScore W2897760136C126322002 @default.
• W2897760136 hasConceptScore W2897760136C153911025 @default.
• W2897760136 hasConceptScore W2897760136C159654299 @default.
• W2897760136 hasConceptScore W2897760136C167672396 @default.
• W2897760136 hasConceptScore W2897760136C203014093 @default.
• W2897760136 hasConceptScore W2897760136C2776090121 @default.
• W2897760136 hasConceptScore W2897760136C2776819417 @default.
• W2897760136 hasConceptScore W2897760136C2778453870 @default.
• W2897760136 hasConceptScore W2897760136C2778690821 @default.
• W2897760136 hasConceptScore W2897760136C2780640218 @default.
• W2897760136 hasConceptScore W2897760136C2781101188 @default.
• W2897760136 hasConceptScore W2897760136C54355233 @default.
• W2897760136 hasConceptScore W2897760136C553184892 @default.
• W2897760136 hasConceptScore W2897760136C71924100 @default.
• W2897760136 hasConceptScore W2897760136C81885089 @default.

• next