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• W2897764155 abstract "BackgroundRecent large-scale clinical studies demonstrate that sodium-glucose cotransporter 2 (SGLT2) inhibitors protect the diabetic kidney. However, clinical and animal studies have not shown the changes of the total glomeruli in the whole kidney treated with SGLT2 inhibitors.MethodsWe performed computed tomography (CT) imaging on mice using synchrotron radiation to investigate the impact of luseogliflozin, a SGLT2 inhibitor, on the number and volume of glomeruli in the whole kidney.FindingsWe did not observe a significant difference in the total glomerular number (Nglom) among mice. Luseogliflozin redistributed the number of glomeruli in different regions, accompanied by the normalization of diabetes-augmented renal volume (Vkidney). Diabetic db/db mice had a larger glomerular volume in the mid-cortex than did control db/m mice, and luseogliflozin increased the glomerular volume in all renal cortical zones of the whole kidney in db/db mice. According to the multivariate regression analysis, hemoglobin A1c level was the most relevant determinant of Vkidney, not Nglom or mean glomerular volume (Vglom), indicating that hyperglycemia induced renal (tubular) hypertrophy, but not glomerular enlargement. Luseogliflozin increased hypoxia in the juxtamedullary region, sustained upregulated renal renin expression and plasma renin activity, and failed to decrease albuminuria by downregulating megalin in db/db mice.InterpretationBased on our findings, SGLT2 inhibitors may alter glomerular distribution and size in addition to their glucose-lowering effects, presumably by affecting oxygen metabolism and humoral factors.FundFunding for this research was provided by The Japan Society for the Promotion of Science, the Japan Diabetes Foundation, and Asahikawa Medical University." @default.
• W2897764155 created "2018-10-26" @default.
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• W2897764155 date "2018-10-01" @default.
• W2897764155 modified "2023-10-14" @default.
• W2897764155 title "Impacts of Diabetes and an SGLT2 Inhibitor on the Glomerular Number and Volume in db/db Mice, as Estimated by Synchrotron Radiation Micro-CT at SPring-8" @default.
• W2897764155 cites W1579701530 @default.
• W2897764155 cites W1888211049 @default.
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• W2897764155 cites W1962535272 @default.
• W2897764155 cites W1963970330 @default.
• W2897764155 cites W1979315000 @default.
• W2897764155 cites W1990025047 @default.
• W2897764155 cites W2007112074 @default.
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• W2897764155 cites W2011409573 @default.
• W2897764155 cites W2019285763 @default.
• W2897764155 cites W2029944512 @default.
• W2897764155 cites W2040181550 @default.
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• W2897764155 cites W2094446617 @default.
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• W2897764155 cites W2113607643 @default.
• W2897764155 cites W2113664327 @default.
• W2897764155 cites W2126020844 @default.
• W2897764155 cites W2131011755 @default.
• W2897764155 cites W2135985828 @default.
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• W2897764155 cites W2154254002 @default.
• W2897764155 cites W2158458517 @default.
• W2897764155 cites W2162190889 @default.
• W2897764155 cites W2164368208 @default.
• W2897764155 cites W2173187023 @default.
• W2897764155 cites W2189240652 @default.
• W2897764155 cites W2195252126 @default.
• W2897764155 cites W2253220599 @default.
• W2897764155 cites W2400870857 @default.
• W2897764155 cites W2403697735 @default.
• W2897764155 cites W2406883486 @default.
• W2897764155 cites W2424539745 @default.
• W2897764155 cites W2472425605 @default.
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• W2897764155 doi "https://doi.org/10.1016/j.ebiom.2018.09.048" @default.
• W2897764155 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6197731" @default.
• W2897764155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30322799" @default.
• W2897764155 hasPublicationYear "2018" @default.
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