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- W2897766055 abstract "Cerebral amyloid angiopathy (CAA) is a vascular neuropathology commonly reported in non-cognitively impaired (NCI), mild cognitive impairment (MCI) and Alzheimer's disease (AD) brains. Although previous studies report that the presence of CAA affects cognition in MCI and AD subjects, an association between non-demented elderly subjects that display either limited or extensive AD pathology, remain unclear. This study determined the association between CAA and a cognitive composite score among a cohort of elderly NCI subjects with a differing extent of AD lesions. 182 autopsy cases from the Rush Religious Order Study were analyzed. All subjects were NCI at their first clinical assessment. At time of death, 98 subjects remained NCI while 84 progressed to either MCI (n = 40) or AD (n = 44). A cognitive composite score was used to measure cognitive change over time. CAA was dichotomized (present/absent) based upon a standard 0 to 3 severity scale used as a predictor variable along with dementia progression and other demographic covariates. Cases were also grouped according to neuritic plaque (NP) and neurofibrillary tangle (NFT) load. A mixed model-repeated measures analysis was used to assess change from baseline on the cognitive composite score. CAA individuals with high NP scores had significantly greater composite score change from baseline relative to the low NP group [-3.52 (95% CI: -5.85, -1.18), p = 0.003]. Those cases without CAA were not different between the low and high NP groups [-3.19 (95% CI: -9.15, -2.76), p = 0.29]. By contrast, change from baseline between the high and low NFT groups with [3.13 (95% CI: -3.42, 9.68), p = 0.35] or without [-0.69 (95% CI: -3.03, 1.65), p = 0.56] CAA were not significantly different. CAA and high NP load, but not NFTs are associated with greater decline on a cognitive composite score. Accounting for the presence of CAA may be important in assessing treatment efficacy in AD prevention trials." @default.
- W2897766055 created "2018-10-26" @default.
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- W2897766055 date "2018-07-01" @default.
- W2897766055 modified "2023-10-16" @default.
- W2897766055 title "O2‐03‐04: CEREBRAL AMYLOID ANGIOPATHY CORRELATES WITH COGNITIVE DECLINE IN PRECLINICAL AD" @default.
- W2897766055 doi "https://doi.org/10.1016/j.jalz.2018.06.2654" @default.
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