Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897766883> ?p ?o ?g. }
- W2897766883 endingPage "253" @default.
- W2897766883 startingPage "245" @default.
- W2897766883 abstract "Objective: Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers. Bipolar depression manifests systemic inflammation, mitochondrial dysfunction, and changes in brain growth factors. The depressive phase of the disorder is the most common and responds the least to conventional treatments. Garcinia mangostana Linn, commonly known as mangosteen, is a tropical fruit. The pericarp’s properties may reduce oxidative stress and inflammation and improve neurogenesis, making mangosteen pericarp a promising add-on therapy for bipolar depression. Methods: Participants will receive 24 weeks of either 1,000 mg mangosteen pericarp or placebo per day, in addition to their usual treatment. The primary outcome is change in severity of mood symptoms, measured using the Montgomery-Åsberg Depression Rating Scale (MADRS), over the treatment phase. Secondary outcomes include global psychopathology, quality of life, functioning, substance use, cognition, safety, biological data, and cost-effectiveness. A follow-up interview will be conducted 4 weeks post-treatment. Conclusion: The findings of this study may have implications for improving treatment outcomes for those with bipolar disorder and may contribute to our understanding of the pathophysiology of bipolar depression. Clinical trial registration: Australian and New Zealand Clinical Trial Registry, ACTRN12616000028404." @default.
- W2897766883 created "2018-10-26" @default.
- W2897766883 creator A5001792674 @default.
- W2897766883 creator A5013936218 @default.
- W2897766883 creator A5015532195 @default.
- W2897766883 creator A5016198159 @default.
- W2897766883 creator A5022845535 @default.
- W2897766883 creator A5030341813 @default.
- W2897766883 creator A5038776015 @default.
- W2897766883 creator A5040380494 @default.
- W2897766883 creator A5040586151 @default.
- W2897766883 creator A5042812626 @default.
- W2897766883 creator A5051813961 @default.
- W2897766883 creator A5054672494 @default.
- W2897766883 creator A5057589235 @default.
- W2897766883 creator A5060207911 @default.
- W2897766883 creator A5075256670 @default.
- W2897766883 creator A5078619821 @default.
- W2897766883 creator A5078882374 @default.
- W2897766883 creator A5081907162 @default.
- W2897766883 creator A5091303329 @default.
- W2897766883 date "2019-05-01" @default.
- W2897766883 modified "2023-10-14" @default.
- W2897766883 title "Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial" @default.
- W2897766883 cites W133618362 @default.
- W2897766883 cites W143336295 @default.
- W2897766883 cites W1553321123 @default.
- W2897766883 cites W1973652904 @default.
- W2897766883 cites W1973995678 @default.
- W2897766883 cites W1984287335 @default.
- W2897766883 cites W1986211748 @default.
- W2897766883 cites W1998565470 @default.
- W2897766883 cites W2000555003 @default.
- W2897766883 cites W2007379414 @default.
- W2897766883 cites W2026977189 @default.
- W2897766883 cites W2030034545 @default.
- W2897766883 cites W2049365002 @default.
- W2897766883 cites W2057439779 @default.
- W2897766883 cites W2058634928 @default.
- W2897766883 cites W2059051998 @default.
- W2897766883 cites W2061378977 @default.
- W2897766883 cites W2071830609 @default.
- W2897766883 cites W2075933179 @default.
- W2897766883 cites W2091455054 @default.
- W2897766883 cites W2093274439 @default.
- W2897766883 cites W2095670320 @default.
- W2897766883 cites W2102596998 @default.
- W2897766883 cites W2121304943 @default.
- W2897766883 cites W2123676882 @default.
- W2897766883 cites W2130159618 @default.
- W2897766883 cites W2131671310 @default.
- W2897766883 cites W2131823335 @default.
- W2897766883 cites W2142476463 @default.
- W2897766883 cites W2151735632 @default.
- W2897766883 cites W2156064382 @default.
- W2897766883 cites W2161282771 @default.
- W2897766883 cites W2166023752 @default.
- W2897766883 cites W2167659819 @default.
- W2897766883 cites W2171019609 @default.
- W2897766883 cites W2216679151 @default.
- W2897766883 cites W2416086090 @default.
- W2897766883 cites W2520122909 @default.
- W2897766883 cites W2620573669 @default.
- W2897766883 cites W2740717143 @default.
- W2897766883 cites W2766919206 @default.
- W2897766883 cites W4320800471 @default.
- W2897766883 cites W1996955131 @default.
- W2897766883 doi "https://doi.org/10.1590/1516-4446-2018-0114" @default.
- W2897766883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6794139" @default.
- W2897766883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30328970" @default.
- W2897766883 hasPublicationYear "2019" @default.
- W2897766883 type Work @default.
- W2897766883 sameAs 2897766883 @default.
- W2897766883 citedByCount "7" @default.
- W2897766883 countsByYear W28977668832019 @default.
- W2897766883 countsByYear W28977668832020 @default.
- W2897766883 countsByYear W28977668832021 @default.
- W2897766883 countsByYear W28977668832022 @default.
- W2897766883 crossrefType "journal-article" @default.
- W2897766883 hasAuthorship W2897766883A5001792674 @default.
- W2897766883 hasAuthorship W2897766883A5013936218 @default.
- W2897766883 hasAuthorship W2897766883A5015532195 @default.
- W2897766883 hasAuthorship W2897766883A5016198159 @default.
- W2897766883 hasAuthorship W2897766883A5022845535 @default.
- W2897766883 hasAuthorship W2897766883A5030341813 @default.
- W2897766883 hasAuthorship W2897766883A5038776015 @default.
- W2897766883 hasAuthorship W2897766883A5040380494 @default.
- W2897766883 hasAuthorship W2897766883A5040586151 @default.
- W2897766883 hasAuthorship W2897766883A5042812626 @default.
- W2897766883 hasAuthorship W2897766883A5051813961 @default.
- W2897766883 hasAuthorship W2897766883A5054672494 @default.
- W2897766883 hasAuthorship W2897766883A5057589235 @default.
- W2897766883 hasAuthorship W2897766883A5060207911 @default.
- W2897766883 hasAuthorship W2897766883A5075256670 @default.
- W2897766883 hasAuthorship W2897766883A5078619821 @default.
- W2897766883 hasAuthorship W2897766883A5078882374 @default.
- W2897766883 hasAuthorship W2897766883A5081907162 @default.
- W2897766883 hasAuthorship W2897766883A5091303329 @default.