FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897767719> ?p ?o ?g. }

• W2897767719 abstract "Sleep disorder is confirmed as a core component of Alzheimer's disease (AD), while the accumulation of amyloid β (Aβ) in brain tissue is an important pathological feature of AD. However, how Aβ affects AD‑associated sleep disorder is not yet well understood. In the present study, experiments on animal and cell models were performed to detect the association between sleep disorder and Aβ. It was observed that Aβ25‑35 administration significantly decreased non‑rapid eye movement sleep, while it increased wakefulness in mice. In addition, reverse transcription‑quantitative polymerase chain reaction and western blot analysis revealed that the expression levels of tau, p‑tau, orexin A and orexin neurons express adenosine A1 receptor (A1R) were markedly upregulated in the brain tissue of AD mice compared with that in samples obtained from control mice. Furthermore, the in vitro study revealed that the expression levels of tau, p‑tau, orexin A and adenosine A1R were also significantly increased in human neuroblastoma SH‑SY5Y cells treated with Aβ25‑35 as compared with the control cells. In addition, the tau inhibitor TRx 0237 significantly reversed the promoting effects of Aβ25‑35 on tau, p‑tau, orexin A and adenosine A1R expression levels, and adenosine A1R or orexin A knockdown also inhibited tau and p‑tau expression levels mediated by Aβ25‑35 in AD. These results indicate that Aβ and tau may be considered as novel biomarkers of sleep disorder in AD pathology, and that they function by regulating the expression levels of orexin A and adenosine A1R." @default.
• W2897767719 created "2018-10-26" @default.
• W2897767719 creator A5031593335 @default.
• W2897767719 creator A5064408814 @default.
• W2897767719 creator A5083980378 @default.
• W2897767719 creator A5085222557 @default.
• W2897767719 creator A5085657273 @default.
• W2897767719 date "2018-10-16" @default.
• W2897767719 modified "2023-10-03" @default.
• W2897767719 title "Amyloid�β and tau are involved in sleep disorder in Alzheimer's disease by orexin�A and adenosine A(1) receptor" @default.
• W2897767719 cites W1011299157 @default.
• W2897767719 cites W196569618 @default.
• W2897767719 cites W1979068994 @default.
• W2897767719 cites W1981681682 @default.
• W2897767719 cites W2000474416 @default.
• W2897767719 cites W2002293846 @default.
• W2897767719 cites W2013333500 @default.
• W2897767719 cites W2019289857 @default.
• W2897767719 cites W2019506702 @default.
• W2897767719 cites W2025144540 @default.
• W2897767719 cites W2027740042 @default.
• W2897767719 cites W2052742260 @default.
• W2897767719 cites W2053116497 @default.
• W2897767719 cites W2054726866 @default.
• W2897767719 cites W2066529264 @default.
• W2897767719 cites W2076231255 @default.
• W2897767719 cites W2077676121 @default.
• W2897767719 cites W2081103834 @default.
• W2897767719 cites W2086238474 @default.
• W2897767719 cites W2100743305 @default.
• W2897767719 cites W2107277218 @default.
• W2897767719 cites W2108794414 @default.
• W2897767719 cites W2109133215 @default.
• W2897767719 cites W2122320288 @default.
• W2897767719 cites W2123400726 @default.
• W2897767719 cites W2152211310 @default.
• W2897767719 cites W2159947664 @default.
• W2897767719 cites W2160311930 @default.
• W2897767719 cites W2265194371 @default.
• W2897767719 cites W2331311576 @default.
• W2897767719 cites W2440154114 @default.
• W2897767719 cites W2512883334 @default.
• W2897767719 cites W2561913540 @default.
• W2897767719 cites W2562749640 @default.
• W2897767719 cites W2781382271 @default.
• W2897767719 cites W2788876766 @default.
• W2897767719 cites W2791129016 @default.
• W2897767719 cites W78741198 @default.
• W2897767719 doi "https://doi.org/10.3892/ijmm.2018.3935" @default.
• W2897767719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30365112" @default.
• W2897767719 hasPublicationYear "2018" @default.
• W2897767719 type Work @default.
• W2897767719 sameAs 2897767719 @default.
• W2897767719 citedByCount "22" @default.
• W2897767719 countsByYear W28977677192019 @default.
• W2897767719 countsByYear W28977677192020 @default.
• W2897767719 countsByYear W28977677192021 @default.
• W2897767719 countsByYear W28977677192022 @default.
• W2897767719 countsByYear W28977677192023 @default.
• W2897767719 crossrefType "journal-article" @default.
• W2897767719 hasAuthorship W2897767719A5031593335 @default.
• W2897767719 hasAuthorship W2897767719A5064408814 @default.
• W2897767719 hasAuthorship W2897767719A5083980378 @default.
• W2897767719 hasAuthorship W2897767719A5085222557 @default.
• W2897767719 hasAuthorship W2897767719A5085657273 @default.
• W2897767719 hasBestOaLocation W28977677191 @default.
• W2897767719 hasConcept C118303440 @default.
• W2897767719 hasConcept C126322002 @default.
• W2897767719 hasConcept C134018914 @default.
• W2897767719 hasConcept C158424129 @default.
• W2897767719 hasConcept C170493617 @default.
• W2897767719 hasConcept C182683403 @default.
• W2897767719 hasConcept C185592680 @default.
• W2897767719 hasConcept C2776119998 @default.
• W2897767719 hasConcept C2776991684 @default.
• W2897767719 hasConcept C2778670691 @default.
• W2897767719 hasConcept C2778938600 @default.
• W2897767719 hasConcept C2779134260 @default.
• W2897767719 hasConcept C2779605129 @default.
• W2897767719 hasConcept C2779680196 @default.
• W2897767719 hasConcept C502032728 @default.
• W2897767719 hasConcept C67907053 @default.
• W2897767719 hasConcept C71924100 @default.
• W2897767719 hasConcept C86803240 @default.
• W2897767719 hasConceptScore W2897767719C118303440 @default.
• W2897767719 hasConceptScore W2897767719C126322002 @default.
• W2897767719 hasConceptScore W2897767719C134018914 @default.
• W2897767719 hasConceptScore W2897767719C158424129 @default.
• W2897767719 hasConceptScore W2897767719C170493617 @default.
• W2897767719 hasConceptScore W2897767719C182683403 @default.
• W2897767719 hasConceptScore W2897767719C185592680 @default.
• W2897767719 hasConceptScore W2897767719C2776119998 @default.
• W2897767719 hasConceptScore W2897767719C2776991684 @default.
• W2897767719 hasConceptScore W2897767719C2778670691 @default.
• W2897767719 hasConceptScore W2897767719C2778938600 @default.
• W2897767719 hasConceptScore W2897767719C2779134260 @default.
• W2897767719 hasConceptScore W2897767719C2779605129 @default.
• W2897767719 hasConceptScore W2897767719C2779680196 @default.
• W2897767719 hasConceptScore W2897767719C502032728 @default.
• W2897767719 hasConceptScore W2897767719C67907053 @default.

• next