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• W2897767915 abstract "Recent clinical reports suggest that positron emission tomography (PET) of tau pathologies could offer an in vivo biomarker for monitoring and/or predicting the progression of Alzheimer's disease (AD) spectrum. To examine this notion in a longitudinal setting, we performed a time-course PET study using 11C-pyridinyl-butadienyl-benzothiazole 3 (PBB3), a radioligand for tau lesions, in cognitively healthy controls (HCs) and early AD-spectrum patients. Eight HCs and 10 patients with mild cognitive impairment (MCI) underwent baseline PET scans with 11C-PBB3 and 11C-Pittsburgh compound-B (PiB) for estimating tau and amyloid β depositions. All subjects except PiB(-) MCI cases also received follow-up scans approximately 2 years after the baseline assay. Retention of PBB3 and PiB in volumes of interest (VOIs) corresponding to mean cortical and Braak-stage I/II, III/IV and V/VI areas were quantified by determining standardized uptake ratios (SUVRs) to the cerebellar cortex. A stepwise linear regression analysis was performed to investigate associations of PET measures with clinical and demographic variables. One PiB(-) and one PiB(+) HCs at baseline progressed to PiB(+) MCI in the follow-up. Four of 10 MCI subjects were PiB(+) at baseline, consisting of two converters to AD and two non-converters. We accordingly classified these six subjects showing PiB positivity in the baseline and/or follow-up analyses as AD-spectrum patients. Six HCs were PiB(-) in both baseline and follow-up scans, and were classified as amyloid(-) HCs. The AD-spectrum group exhibited significantly higher baseline PBB3 SUVRs of mean cortical and Braak V/VI VOIs than the amyloid(-) HC group, and these values were further elevated in the follow-up scan. A stepwise linear regression analysis showed that mean cortical PBB3 SUVR at baseline correlated with annual changes of Clinical Dementia Rating Scale Sum of Boxes Scores, while there were no overt correlations between chronological changes of PBB3 SUVRs and clinical and neuropsychological scores. Longitudinal PBB3-PET could track the spreading of tau depositions in the advancement of AD spectrum. The baseline tau burden allowed prediction of the clinical disease progression, implying that the rapidness of early-stage tau accumulations by the time of the baseline scan determines the aggressiveness of subsequent functional deteriorations." @default.
• W2897767915 created "2018-10-26" @default.
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• W2897767915 date "2018-07-01" @default.
• W2897767915 modified "2023-10-16" @default.
• W2897767915 title "IC‐P‐221: TAU ACCUMULATION PREDICTS PROGRESSION OF DEMENTIA IN SUBJECTS WITH EARLY ALZHEIMER'S DISEASE IN THE ALZHEIMER'S DISEASE SPECTRUM: A [ ¹¹ C]PBB3 POSITRON EMISSION TOMOGRAPHY STUDY" @default.
• W2897767915 doi "https://doi.org/10.1016/j.jalz.2018.06.2288" @default.
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