Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897770282> ?p ?o ?g. }
- W2897770282 endingPage "200" @default.
- W2897770282 startingPage "186" @default.
- W2897770282 abstract "In this study we investigated the possibility of using polyelectrolytes with antibacterial properties to form layer-by-layer (LbL) coatings on contact lens materials with the objective of controlling the release of ophthalmic drugs, while minimizing bacterial growth. A silicone-based hydrogel recently proposed by our group was chosen as a drug releasing soft contact lens (SCL) material and three drugs were tested: moxifloxacin hydrochloride (MXF), chlorhexidine diacetate monohydrate (CHX), and diclofenac sodium salt (DIC). Employed coatings involved combinations of sodium alginate (ALG), chitosan (CHI), sodium hyaluronate (HA) and polylysine hydrobromide (PLL), using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as a cross-linking agent. Controlled release of DIC was achieved using two double layers of the following combinations: ALG/PLL (EDC), HA (EDC)/CHI and HA/PLL (EDC) + Drug. Furthermore, the physical properties of the coated lens material were kept, or even improved, and bacterial growth was reduced. In contrast, these coatings did not retard the release of MXF and CHX. The specificity of the barrier effect of these LbL films for DIC may be attributed to the formation of reversible interactions between DIC and the polyelectrolyte chains. A top layer of HA was needed to reduce the interaction with tear proteins. The in vivo efficacy of a contact lens coated with ALG/PLL (EDC)//HA and loaded with DIC was predicted using a simplified mathematical model to estimate the drug concentration in the tear fluid. The period of time during which the estimated concentration of DIC remained above the half-maximum inhibitory concentrations for the active enzymes in the process of inflammation, was at least double that obtained with the uncoated sample." @default.
- W2897770282 created "2018-10-26" @default.
- W2897770282 creator A5001190640 @default.
- W2897770282 creator A5024969314 @default.
- W2897770282 creator A5025824279 @default.
- W2897770282 creator A5028852384 @default.
- W2897770282 creator A5074765393 @default.
- W2897770282 creator A5087018197 @default.
- W2897770282 date "2018-12-01" @default.
- W2897770282 modified "2023-09-30" @default.
- W2897770282 title "Antibacterial layer-by-layer coatings to control drug release from soft contact lenses material" @default.
- W2897770282 cites W1436882762 @default.
- W2897770282 cites W1472937122 @default.
- W2897770282 cites W1823878404 @default.
- W2897770282 cites W1966416481 @default.
- W2897770282 cites W1969556666 @default.
- W2897770282 cites W1969711710 @default.
- W2897770282 cites W1970625396 @default.
- W2897770282 cites W1972801619 @default.
- W2897770282 cites W1979893432 @default.
- W2897770282 cites W1979978944 @default.
- W2897770282 cites W1981974544 @default.
- W2897770282 cites W1988871507 @default.
- W2897770282 cites W1990589377 @default.
- W2897770282 cites W1994051469 @default.
- W2897770282 cites W1997112112 @default.
- W2897770282 cites W1998624348 @default.
- W2897770282 cites W1999220050 @default.
- W2897770282 cites W1999413921 @default.
- W2897770282 cites W2005388396 @default.
- W2897770282 cites W2014797211 @default.
- W2897770282 cites W2030117818 @default.
- W2897770282 cites W2031409415 @default.
- W2897770282 cites W2038851042 @default.
- W2897770282 cites W2042202309 @default.
- W2897770282 cites W2051023112 @default.
- W2897770282 cites W2051649984 @default.
- W2897770282 cites W2051802124 @default.
- W2897770282 cites W2053869522 @default.
- W2897770282 cites W2057945718 @default.
- W2897770282 cites W2063162284 @default.
- W2897770282 cites W2068388837 @default.
- W2897770282 cites W2078253468 @default.
- W2897770282 cites W2079745748 @default.
- W2897770282 cites W2082993126 @default.
- W2897770282 cites W2084870857 @default.
- W2897770282 cites W2084997955 @default.
- W2897770282 cites W2090568896 @default.
- W2897770282 cites W2092698254 @default.
- W2897770282 cites W2094279111 @default.
- W2897770282 cites W2107709133 @default.
- W2897770282 cites W2108758866 @default.
- W2897770282 cites W2115231871 @default.
- W2897770282 cites W2116065352 @default.
- W2897770282 cites W2131978067 @default.
- W2897770282 cites W2132117442 @default.
- W2897770282 cites W2134276393 @default.
- W2897770282 cites W2145877521 @default.
- W2897770282 cites W2155059251 @default.
- W2897770282 cites W2162097998 @default.
- W2897770282 cites W2170101626 @default.
- W2897770282 cites W2237504748 @default.
- W2897770282 cites W2282890457 @default.
- W2897770282 cites W2309402333 @default.
- W2897770282 cites W2323103686 @default.
- W2897770282 cites W2499468836 @default.
- W2897770282 cites W2527142761 @default.
- W2897770282 cites W4299899574 @default.
- W2897770282 doi "https://doi.org/10.1016/j.ijpharm.2018.10.041" @default.
- W2897770282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30342082" @default.
- W2897770282 hasPublicationYear "2018" @default.
- W2897770282 type Work @default.
- W2897770282 sameAs 2897770282 @default.
- W2897770282 citedByCount "30" @default.
- W2897770282 countsByYear W28977702822019 @default.
- W2897770282 countsByYear W28977702822020 @default.
- W2897770282 countsByYear W28977702822021 @default.
- W2897770282 countsByYear W28977702822022 @default.
- W2897770282 countsByYear W28977702822023 @default.
- W2897770282 crossrefType "journal-article" @default.
- W2897770282 hasAuthorship W2897770282A5001190640 @default.
- W2897770282 hasAuthorship W2897770282A5024969314 @default.
- W2897770282 hasAuthorship W2897770282A5025824279 @default.
- W2897770282 hasAuthorship W2897770282A5028852384 @default.
- W2897770282 hasAuthorship W2897770282A5074765393 @default.
- W2897770282 hasAuthorship W2897770282A5087018197 @default.
- W2897770282 hasConcept C118487528 @default.
- W2897770282 hasConcept C127413603 @default.
- W2897770282 hasConcept C13965031 @default.
- W2897770282 hasConcept C153356533 @default.
- W2897770282 hasConcept C159985019 @default.
- W2897770282 hasConcept C163588942 @default.
- W2897770282 hasConcept C171250308 @default.
- W2897770282 hasConcept C178790620 @default.
- W2897770282 hasConcept C185592680 @default.
- W2897770282 hasConcept C188027245 @default.
- W2897770282 hasConcept C192562407 @default.
- W2897770282 hasConcept C2775997276 @default.