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- W28977709 abstract "Prostate cancer usually presents with early-stage disease, yet a significant proportion of patients present or will progress to androgen-independent, nonmetastatic prostate cancer (AIPC). Chemotherapy has demonstrated statistically significant improvements in palliation of AIPC. Docetaxel in particular has demonstrated high response rates as a single agent. Thalidomide is effective in treating many malignancies, including prostate cancer. Thalidomide may act synergistically with docetaxel through their antiangiogenic effects. We performed a phase II trial of docetaxel with or without thalidomide in patients with AIPC and demonstrated encouraging response rates with combination therapy. We advocate further investigation of this promising combination regimen." @default.
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- W28977709 date "2003-01-01" @default.
- W28977709 modified "2023-09-23" @default.
- W28977709 title "Docetaxel and thalidomide as a treatment option for androgen- independent, nonmetastatic prostate cancer." @default.
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