FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897777487> ?p ?o ?g. }

• W2897777487 endingPage "44" @default.
• W2897777487 startingPage "31" @default.
• W2897777487 abstract "Introduction: Carboxyalkyl flavonoids derivatives are considered as effective inhibitors in reducing post-prandial hyperglycaemia. Methods: Combined with Density Functional Theory (DFT) and the theory of Atoms in Molecules (AIM), molecular docking and charge density analysis are carried out to understand the molecular flexibility, charge density distribution and the electrostatic properties of these carboxyalkyl derivatives. Results: Results show that the electron density of the chemical bond C14-O17 on B ring of molecule II increases while O17-H18 decreases at the active site, suggesting the existence of weak noncovalent interactions, most prominent of which are H-bonding and electrostatic interaction. When hydroxyl groups are introduced, the highest positive electrostatic potentials are distributed near the B ring hydroxyl hydrogen atom and the carboxyl hydrogen atom on the A ring. It was reported that quercetin has a considerably inhibitory activity to S. cerevisiae α-glucosidase, from the binding affinities, it is suggested that the position and number of hydroxyl groups on the B and C rings are also pivotal to the hypoglycemic activity when the long carboxyalkyl group is introduced into the A ring. Conclusion: It is concluded that the presence of three well-defined zones in the structure, both hydrophobicity alkyl, hydrophilicity carboxyl and hydroxyl groups are necessary." @default.
• W2897777487 created "2018-10-26" @default.
• W2897777487 creator A5009445678 @default.
• W2897777487 creator A5011805835 @default.
• W2897777487 creator A5025977200 @default.
• W2897777487 creator A5033338808 @default.
• W2897777487 date "2020-01-06" @default.
• W2897777487 modified "2023-09-27" @default.
• W2897777487 title "Effects of Hydroxyl Group on the Interaction of Carboxylated Flavonoid Derivatives with S. Cerevisiae α-Glucosidase" @default.
• W2897777487 cites W1968900407 @default.
• W2897777487 cites W1974846806 @default.
• W2897777487 cites W1977956372 @default.
• W2897777487 cites W1988909822 @default.
• W2897777487 cites W1991048885 @default.
• W2897777487 cites W2000651005 @default.
• W2897777487 cites W2013722208 @default.
• W2897777487 cites W2022498424 @default.
• W2897777487 cites W2022521911 @default.
• W2897777487 cites W2025820280 @default.
• W2897777487 cites W2027414936 @default.
• W2897777487 cites W2041950013 @default.
• W2897777487 cites W2044375562 @default.
• W2897777487 cites W2056007969 @default.
• W2897777487 cites W2058471052 @default.
• W2897777487 cites W2077019074 @default.
• W2897777487 cites W2084205148 @default.
• W2897777487 cites W2092955693 @default.
• W2897777487 cites W2096962718 @default.
• W2897777487 cites W2105668062 @default.
• W2897777487 cites W2132525235 @default.
• W2897777487 cites W2135384670 @default.
• W2897777487 cites W2143066955 @default.
• W2897777487 cites W2147461095 @default.
• W2897777487 cites W2149600527 @default.
• W2897777487 cites W2153617234 @default.
• W2897777487 cites W2168195570 @default.
• W2897777487 cites W2191975899 @default.
• W2897777487 cites W2194185631 @default.
• W2897777487 cites W2228230210 @default.
• W2897777487 cites W2266494150 @default.
• W2897777487 cites W2276233679 @default.
• W2897777487 cites W2301071904 @default.
• W2897777487 cites W2340667615 @default.
• W2897777487 cites W2376278384 @default.
• W2897777487 cites W2502591428 @default.
• W2897777487 cites W2510700349 @default.
• W2897777487 cites W2515731681 @default.
• W2897777487 cites W2527038151 @default.
• W2897777487 cites W2548694282 @default.
• W2897777487 cites W2588341308 @default.
• W2897777487 cites W2606455133 @default.
• W2897777487 cites W2608753225 @default.
• W2897777487 cites W2613977845 @default.
• W2897777487 cites W2740251179 @default.
• W2897777487 cites W2750967466 @default.
• W2897777487 cites W2759298922 @default.
• W2897777487 cites W2806660223 @default.
• W2897777487 cites W3082280132 @default.
• W2897777487 cites W331468491 @default.
• W2897777487 cites W2330455457 @default.
• W2897777487 doi "https://doi.org/10.2174/1573409914666181022142553" @default.
• W2897777487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6967131" @default.
• W2897777487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30345924" @default.
• W2897777487 hasPublicationYear "2020" @default.
• W2897777487 type Work @default.
• W2897777487 sameAs 2897777487 @default.
• W2897777487 citedByCount "9" @default.
• W2897777487 countsByYear W28977774872021 @default.
• W2897777487 countsByYear W28977774872022 @default.
• W2897777487 countsByYear W28977774872023 @default.
• W2897777487 crossrefType "journal-article" @default.
• W2897777487 hasAuthorship W2897777487A5009445678 @default.
• W2897777487 hasAuthorship W2897777487A5011805835 @default.
• W2897777487 hasAuthorship W2897777487A5025977200 @default.
• W2897777487 hasAuthorship W2897777487A5033338808 @default.
• W2897777487 hasBestOaLocation W28977774872 @default.
• W2897777487 hasConcept C112887158 @default.
• W2897777487 hasConcept C121332964 @default.
• W2897777487 hasConcept C137277065 @default.
• W2897777487 hasConcept C147597530 @default.
• W2897777487 hasConcept C150708132 @default.
• W2897777487 hasConcept C152365726 @default.
• W2897777487 hasConcept C178790620 @default.
• W2897777487 hasConcept C185592680 @default.
• W2897777487 hasConcept C2776640939 @default.
• W2897777487 hasConcept C2780263894 @default.
• W2897777487 hasConcept C2780378348 @default.
• W2897777487 hasConcept C32909587 @default.
• W2897777487 hasConcept C62520636 @default.
• W2897777487 hasConcept C71240020 @default.
• W2897777487 hasConceptScore W2897777487C112887158 @default.
• W2897777487 hasConceptScore W2897777487C121332964 @default.
• W2897777487 hasConceptScore W2897777487C137277065 @default.
• W2897777487 hasConceptScore W2897777487C147597530 @default.
• W2897777487 hasConceptScore W2897777487C150708132 @default.
• W2897777487 hasConceptScore W2897777487C152365726 @default.
• W2897777487 hasConceptScore W2897777487C178790620 @default.
• W2897777487 hasConceptScore W2897777487C185592680 @default.

• next