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• W2897777717 endingPage "20180352" @default.
• W2897777717 startingPage "20180352" @default.
• W2897777717 abstract "Low and oscillatory wall shear stress (WSS) has long been hypothesized as a risk factor for atherosclerosis; however, evidence has been inferred primarily from model and post-mortem studies, or clinical studies of patients with already-developed plaques. This study aimed to identify associations between local haemodynamic and imaging markers of early atherosclerosis. Comprehensive magnetic resonance imaging allowed quantification of contrast enhancement (CE) (a marker of endothelial dysfunction) and vessel wall thickness at two distinct segments: the internal carotid artery bulb and the common carotid artery (CCA). Strict criteria were applied to a large dataset to exclude inward remodelling, resulting in 41 cases for which personalized computational fluid dynamic simulations were performed. After controlling for cardiovascular risk factors, bulb wall thickening was found to be weakly, but not significantly, associated with oscillatory WSS. CE at the bulb was significantly associated with low WSS ( p < 0.001) and low flow helicity ( p < 0.05). No significant associations were found for the CCA segment. Local haemodynamics at the bulb were significantly correlated with blood flow rates and heart rates, but not carotid bifurcation geometry (flare and curvature). Therefore low, but not oscillatory, WSS is an early independent marker of atherosclerotic changes preceding intimal thickening at the carotid bulb." @default.
• W2897777717 created "2018-10-26" @default.
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• W2897777717 date "2018-10-01" @default.
• W2897777717 modified "2023-10-16" @default.
• W2897777717 title "Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: an <i>in vivo</i> human study" @default.
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• W2897777717 doi "https://doi.org/10.1098/rsif.2018.0352" @default.
• W2897777717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6228482" @default.
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