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• W2897778502 abstract "To compare and report the xerostomia after intensity-modulated radiation therapy (IMRT) or intensity-modulated proton therapy (IMPT) in patients with oropharyngeal cancer and investigate the dosimetric vairables leading to acute or late xerostomia A total of 529 oropharyngeal cancer patients received definitive radiotherapy from January 2011 to August 2015 at MD Anderson Cancer Center (425 IMRT and 104 IMPT). Each patient completed an 8-item self-reported xerostomia-specific questionnaire(XQ) and rated each item on a scale from 0 to 10; The higher the score, the worse the xerostomia. The dosimetric variables and xerostomia were compared with Chi-square test or independent sample T tests. The mean XQ scores of IMPT group were significantly lower at 18-24 and 24-36 months after radiotherapy, compared to IMRT group (22.1 vs 15.8, P =0.032; 23.1 vs 15.1, P =0.014). At 0-3, 3-6, 6-9, 9-12, and 12-18 months after radiotherapy, the mean XQ scores were not significantly different between the two groups. The incidence of XQ scores >40 late xerostomia also was significantly lower in the IMPT group than in the IMRT group: 0% versus 17.3% at 18-24 months (P =0.043); 0% versus 23.1% at 24-36 months (P =0.012). The proportions of XQ scores >40 were similar between the two groups at 0-3, 3-6, 6-9, 9-12, and 12-18 after radiotherapy (34.3% vs 34.1%; 32.7% vs 30.8%; 23.3% vs 20.0%; 18.3% 10.8%; 14.6% vs 12.1%). According to late xerostomia (12 months after radiotherapy), higher V5, V10, V15 and V20 on contra-lateral Parotid were significantly (p <0.05) associated to higher proportion of XQ scores >40. V5 to V50 on contra-lateral parotid are associated to acute xerostomia (0-6 months after radiotherapy). Dosimetric data on ipsi-lateral parotid was not related to both acute and late xerostomia. Compared with IMRT, IMPT delivered lower contralateral parotid V5 (76.4 % vs. 92.5%) with P<0.05 for the patients with late xerostomia data available. IMPT reduces late xerostomia of patients with oropharyngeal cancer. Only contra- not ipsi- lateral parotid dosimetric data are stongly related to both acute and late xerostomia. The significant reduction of late xerostomia by IMPT might be related to lower contra-lateral V5 by IMPT." @default.
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• W2897778502 date "2018-11-01" @default.
• W2897778502 modified "2023-10-18" @default.
• W2897778502 title "The Significant Reduction of Late Xerostomia of Intensity-Modulated Proton Therapy for Oropharyngeal Cancer" @default.
• W2897778502 doi "https://doi.org/10.1016/j.ijrobp.2018.07.729" @default.
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