Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897783849> ?p ?o ?g. }
- W2897783849 abstract "Nitric oxide (NO) orchestrates a plethora of incongruent plant immune responses, including the reprograming of global gene expression. However, the cognate molecular mechanisms remain largely unknown. Here we show a zinc finger transcription factor (ZF-TF), SRG1, is a central target of NO bioactivity during plant immunity, where it functions as a positive regulator. NO accumulation promotes SRG1 expression and subsequently SRG1 occupies a repeated canonical sequence within target promoters. An EAR domain enables SRG1 to recruit the corepressor TOPLESS, suppressing target gene expression. Sustained NO synthesis drives SRG1 S-nitrosylation predominantly at Cys87, relieving both SRG1 DNA binding and transcriptional repression activity. Accordingly, mutation of Cys87 compromises NO-mediated control of SRG1-dependent transcriptional suppression. Thus, the SRG1-SNO formation may contribute to a negative feedback loop that attenuates the plant immune response. SRG1 Cys87 is evolutionary conserved and thus may be a target for redox regulation of ZF-TF function across phylogenetic kingdoms." @default.
- W2897783849 created "2018-10-26" @default.
- W2897783849 creator A5000828698 @default.
- W2897783849 creator A5025661600 @default.
- W2897783849 creator A5036372017 @default.
- W2897783849 creator A5039617968 @default.
- W2897783849 creator A5042590803 @default.
- W2897783849 creator A5045280631 @default.
- W2897783849 creator A5055247536 @default.
- W2897783849 creator A5060130848 @default.
- W2897783849 creator A5072718275 @default.
- W2897783849 date "2018-10-12" @default.
- W2897783849 modified "2023-09-29" @default.
- W2897783849 title "S-nitrosylation of the zinc finger protein SRG1 regulates plant immunity" @default.
- W2897783849 cites W1492951734 @default.
- W2897783849 cites W1575028964 @default.
- W2897783849 cites W1762742043 @default.
- W2897783849 cites W1803425892 @default.
- W2897783849 cites W1906793962 @default.
- W2897783849 cites W1909266661 @default.
- W2897783849 cites W1965166802 @default.
- W2897783849 cites W1967522349 @default.
- W2897783849 cites W1973864912 @default.
- W2897783849 cites W1974830912 @default.
- W2897783849 cites W1976387692 @default.
- W2897783849 cites W1982718914 @default.
- W2897783849 cites W1983379119 @default.
- W2897783849 cites W1985658178 @default.
- W2897783849 cites W1986201963 @default.
- W2897783849 cites W1988448864 @default.
- W2897783849 cites W1991556936 @default.
- W2897783849 cites W1998053175 @default.
- W2897783849 cites W2005355701 @default.
- W2897783849 cites W2006054001 @default.
- W2897783849 cites W2008807830 @default.
- W2897783849 cites W2016907728 @default.
- W2897783849 cites W2019255399 @default.
- W2897783849 cites W2024674223 @default.
- W2897783849 cites W2030447716 @default.
- W2897783849 cites W2030835712 @default.
- W2897783849 cites W2035152216 @default.
- W2897783849 cites W2040852689 @default.
- W2897783849 cites W2050438925 @default.
- W2897783849 cites W2054701523 @default.
- W2897783849 cites W2055086507 @default.
- W2897783849 cites W2057176841 @default.
- W2897783849 cites W2059336476 @default.
- W2897783849 cites W2060259273 @default.
- W2897783849 cites W2073412229 @default.
- W2897783849 cites W2073419452 @default.
- W2897783849 cites W2082112435 @default.
- W2897783849 cites W2082596071 @default.
- W2897783849 cites W2088109541 @default.
- W2897783849 cites W2088975387 @default.
- W2897783849 cites W2090396452 @default.
- W2897783849 cites W2092388446 @default.
- W2897783849 cites W2093019594 @default.
- W2897783849 cites W2095305581 @default.
- W2897783849 cites W2102619095 @default.
- W2897783849 cites W2103191284 @default.
- W2897783849 cites W2109793046 @default.
- W2897783849 cites W2110679525 @default.
- W2897783849 cites W2113380342 @default.
- W2897783849 cites W2132256310 @default.
- W2897783849 cites W2143442828 @default.
- W2897783849 cites W2143689272 @default.
- W2897783849 cites W2146872665 @default.
- W2897783849 cites W2149525061 @default.
- W2897783849 cites W2150668090 @default.
- W2897783849 cites W2155121212 @default.
- W2897783849 cites W2159931676 @default.
- W2897783849 cites W2162899066 @default.
- W2897783849 cites W2168969893 @default.
- W2897783849 cites W2169402853 @default.
- W2897783849 cites W2169919880 @default.
- W2897783849 cites W2170012044 @default.
- W2897783849 cites W2276127939 @default.
- W2897783849 cites W4251587842 @default.
- W2897783849 cites W92508582 @default.
- W2897783849 doi "https://doi.org/10.1038/s41467-018-06578-3" @default.
- W2897783849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6185907" @default.
- W2897783849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315167" @default.
- W2897783849 hasPublicationYear "2018" @default.
- W2897783849 type Work @default.
- W2897783849 sameAs 2897783849 @default.
- W2897783849 citedByCount "54" @default.
- W2897783849 countsByYear W28977838492019 @default.
- W2897783849 countsByYear W28977838492020 @default.
- W2897783849 countsByYear W28977838492021 @default.
- W2897783849 countsByYear W28977838492022 @default.
- W2897783849 countsByYear W28977838492023 @default.
- W2897783849 crossrefType "journal-article" @default.
- W2897783849 hasAuthorship W2897783849A5000828698 @default.
- W2897783849 hasAuthorship W2897783849A5025661600 @default.
- W2897783849 hasAuthorship W2897783849A5036372017 @default.
- W2897783849 hasAuthorship W2897783849A5039617968 @default.
- W2897783849 hasAuthorship W2897783849A5042590803 @default.
- W2897783849 hasAuthorship W2897783849A5045280631 @default.
- W2897783849 hasAuthorship W2897783849A5055247536 @default.
- W2897783849 hasAuthorship W2897783849A5060130848 @default.