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• W2897783849 abstract "Nitric oxide (NO) orchestrates a plethora of incongruent plant immune responses, including the reprograming of global gene expression. However, the cognate molecular mechanisms remain largely unknown. Here we show a zinc finger transcription factor (ZF-TF), SRG1, is a central target of NO bioactivity during plant immunity, where it functions as a positive regulator. NO accumulation promotes SRG1 expression and subsequently SRG1 occupies a repeated canonical sequence within target promoters. An EAR domain enables SRG1 to recruit the corepressor TOPLESS, suppressing target gene expression. Sustained NO synthesis drives SRG1 S-nitrosylation predominantly at Cys87, relieving both SRG1 DNA binding and transcriptional repression activity. Accordingly, mutation of Cys87 compromises NO-mediated control of SRG1-dependent transcriptional suppression. Thus, the SRG1-SNO formation may contribute to a negative feedback loop that attenuates the plant immune response. SRG1 Cys87 is evolutionary conserved and thus may be a target for redox regulation of ZF-TF function across phylogenetic kingdoms." @default.
• W2897783849 created "2018-10-26" @default.
• W2897783849 creator A5000828698 @default.
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• W2897783849 creator A5060130848 @default.
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• W2897783849 date "2018-10-12" @default.
• W2897783849 modified "2023-09-29" @default.
• W2897783849 title "S-nitrosylation of the zinc finger protein SRG1 regulates plant immunity" @default.
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• W2897783849 doi "https://doi.org/10.1038/s41467-018-06578-3" @default.
• W2897783849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6185907" @default.
• W2897783849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315167" @default.
• W2897783849 hasPublicationYear "2018" @default.
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