FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897785871> ?p ?o ?g. }

• W2897785871 endingPage "25" @default.
• W2897785871 startingPage "1" @default.
• W2897785871 abstract "Drug discovery is inherently very risky. The management of these risks can enable the effective use of limited human and monetary resources. A careful attention to risk management in early discovery is especially important given that what happens in the early phases of a project may dictate the course of a research program for months or years. Risk management in early discovery starts with high-level managerial concerns: careful project selection, sufficient staffing and funding, and access to the appropriate instrumentation and tools. Herein we describe the operational elements of risk management that range from the very broad to the extremely specific. These elements have as their base an embedded culture of risk management that extends down to the experiment level, and project ownership in which all researchers anticipate risk, but are not paralyzed by it. In our model, on this base of culture stand the four pillars of early discovery risk management: right libraries, right assays, right series, and right structure-activity relationships. Appropriate attention to these considerations can decrease the risks inherent in early discovery medicinal chemistry, thereby potentially increasing the return on the investment of necessarily finite resources." @default.
• W2897785871 created "2018-10-26" @default.
• W2897785871 creator A5037864989 @default.
• W2897785871 creator A5044704724 @default.
• W2897785871 creator A5087189852 @default.
• W2897785871 date "2018-01-01" @default.
• W2897785871 modified "2023-09-23" @default.
• W2897785871 title "Risk Management in Early Discovery Medicinal Chemistry" @default.
• W2897785871 cites W1516646538 @default.
• W2897785871 cites W1608885177 @default.
• W2897785871 cites W1802503375 @default.
• W2897785871 cites W1981302470 @default.
• W2897785871 cites W1983208005 @default.
• W2897785871 cites W1994711206 @default.
• W2897785871 cites W1996324056 @default.
• W2897785871 cites W1997514006 @default.
• W2897785871 cites W2010469884 @default.
• W2897785871 cites W2014072921 @default.
• W2897785871 cites W2016575780 @default.
• W2897785871 cites W2023050422 @default.
• W2897785871 cites W2027275928 @default.
• W2897785871 cites W2027393938 @default.
• W2897785871 cites W2029935944 @default.
• W2897785871 cites W2031441006 @default.
• W2897785871 cites W2034549041 @default.
• W2897785871 cites W2036922942 @default.
• W2897785871 cites W2040092511 @default.
• W2897785871 cites W2041774091 @default.
• W2897785871 cites W2043509228 @default.
• W2897785871 cites W2062671889 @default.
• W2897785871 cites W2065160119 @default.
• W2897785871 cites W2065367860 @default.
• W2897785871 cites W2068863726 @default.
• W2897785871 cites W2077516539 @default.
• W2897785871 cites W2077542385 @default.
• W2897785871 cites W2081318066 @default.
• W2897785871 cites W2085181735 @default.
• W2897785871 cites W2089966673 @default.
• W2897785871 cites W2090568991 @default.
• W2897785871 cites W2094342376 @default.
• W2897785871 cites W2097449851 @default.
• W2897785871 cites W2100333708 @default.
• W2897785871 cites W2105649494 @default.
• W2897785871 cites W2110426370 @default.
• W2897785871 cites W2113364934 @default.
• W2897785871 cites W2116633922 @default.
• W2897785871 cites W2117691910 @default.
• W2897785871 cites W2123896578 @default.
• W2897785871 cites W2125338916 @default.
• W2897785871 cites W2125691437 @default.
• W2897785871 cites W2127287358 @default.
• W2897785871 cites W2128581376 @default.
• W2897785871 cites W2128879247 @default.
• W2897785871 cites W2153891907 @default.
• W2897785871 cites W2166507757 @default.
• W2897785871 cites W2305755243 @default.
• W2897785871 cites W2325904119 @default.
• W2897785871 cites W2332896222 @default.
• W2897785871 cites W2739895575 @default.
• W2897785871 cites W2758234599 @default.
• W2897785871 cites W2765398514 @default.
• W2897785871 cites W2767773409 @default.
• W2897785871 cites W2774836366 @default.
• W2897785871 cites W2783569768 @default.
• W2897785871 cites W2789422103 @default.
• W2897785871 cites W2791975964 @default.
• W2897785871 cites W2795862001 @default.
• W2897785871 cites W2797018323 @default.
• W2897785871 cites W2801244804 @default.
• W2897785871 cites W2804997423 @default.
• W2897785871 cites W2949243165 @default.
• W2897785871 cites W2951325952 @default.
• W2897785871 cites W38237158 @default.
• W2897785871 cites W4248107770 @default.
• W2897785871 doi "https://doi.org/10.1016/bs.mie.2018.09.012" @default.
• W2897785871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30390795" @default.
• W2897785871 hasPublicationYear "2018" @default.
• W2897785871 type Work @default.
• W2897785871 sameAs 2897785871 @default.
• W2897785871 citedByCount "1" @default.
• W2897785871 countsByYear W28977858712021 @default.
• W2897785871 crossrefType "book-chapter" @default.
• W2897785871 hasAuthorship W2897785871A5037864989 @default.
• W2897785871 hasAuthorship W2897785871A5044704724 @default.
• W2897785871 hasAuthorship W2897785871A5087189852 @default.
• W2897785871 hasConcept C10138342 @default.
• W2897785871 hasConcept C112930515 @default.
• W2897785871 hasConcept C127413603 @default.
• W2897785871 hasConcept C144133560 @default.
• W2897785871 hasConcept C162324750 @default.
• W2897785871 hasConcept C187736073 @default.
• W2897785871 hasConcept C21547014 @default.
• W2897785871 hasConcept C2522767166 @default.
• W2897785871 hasConcept C2777512617 @default.
• W2897785871 hasConcept C32896092 @default.
• W2897785871 hasConcept C41008148 @default.
• W2897785871 hasConcept C60644358 @default.
• W2897785871 hasConcept C74187038 @default.

• next