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- W2897786300 abstract "Vein patterning in the Drosophila wing provides a powerful tool to study regulation of various signaling pathways. Here we show that the ADAMTS extracellular protease AdamTS-B (CG4096) is expressed in the embryonic wing imaginal disc precursor cells and the wing imaginal disc, and functions to inhibit wing vein formation. Knock-down of AdamTS-B displayed posterior crossveins (PCVs) with either extra branches or deltas, or wider PCVs, and a wandering distal tip of the L5 longitudinal vein. Conversely, over-expression of AdamTS-B resulted in a complete absence of the PCV, an incomplete anterior crossvein, and missing distal end of the L5 longitudinal vein. We conclude that AdamTS-B inhibits wing vein formation through negative regulation of signaling pathways, possibly BMP as well as Egfr, displaying the complexity of roles for this family of extracellular proteases." @default.
- W2897786300 created "2018-10-26" @default.
- W2897786300 creator A5008208006 @default.
- W2897786300 creator A5051479234 @default.
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- W2897786300 date "2018-11-02" @default.
- W2897786300 modified "2023-09-26" @default.
- W2897786300 title "The extracellular protease<i>AdamTS-B</i>inhibits vein formation in the Drosophila wing" @default.
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- W2897786300 doi "https://doi.org/10.1002/dvg.23255" @default.
- W2897786300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296002" @default.
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