FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897787692> ?p ?o ?g. }

• W2897787692 abstract "BackgroundAcute critical bleeding is one of the most feared complications during treatment with oral anticoagulating agents. As more patients undergo treatment with anticoagulating agents, critically bleeding episodes in patients with vitamin K antagonists, thrombin inhibitor, or factor Xa inhibitor-inducted coagulopathy will be encountered frequently by physicians. Hence, an effective treatment capable of reversing the iatrogenic coagulopathy in the acute setting is needed. In randomised clinical trials and observational studies, prothrombin complex concentrate has been reported to be superior to other acute interventions, and many guidelines recommend prothrombin complex concentrate in treatment of critically bleeding patients. The aim of this systematic review is to synthesise the evidence of the effects of prothrombin complex concentrate compared with placebo, no intervention, or other treatment options in critically bleeding patients treated with oral anticoagulants.Methods/designA comprehensive search for relevant published literature will be undertaken in Cochrane Central Register of Controlled Trials, MEDLINE, Embase, WHO International Clinical Trials Registry Platform, Science Citation Index, regulatory databases, and trial registers. We will include randomised clinical trials comparing prothrombin complex concentrate versus placebo, no intervention, or other interventions in critically bleeding patients with oral anticoagulant-induced coagulopathy. Data extraction and risk of bias assessment will be handled by two independent review authors. Meta-analysis will be performed as recommended by Cochrane Handbook for Systematic Reviews of Interventions, bias will be assessed with domains, and trial sequential analysis will be conducted to control random errors. Certainty will be assessed by GRADE.DiscussionAs critical bleeding in patients treated with oral anticoagulants is an increasing problem, an up-to-date systematic review evaluating the benefits and harms of prothrombin complex concentrate is urgently needed. It is the hope that this review will be able to guide best practice in treatment and clinical research of these critically bleeding patients.Systematic review registration PROSPERO CRD42018084371" @default.
• W2897787692 created "2018-10-26" @default.
• W2897787692 creator A5013130118 @default.
• W2897787692 creator A5019275846 @default.
• W2897787692 creator A5024824441 @default.
• W2897787692 creator A5026526616 @default.
• W2897787692 creator A5048743789 @default.
• W2897787692 creator A5059880098 @default.
• W2897787692 date "2018-10-20" @default.
• W2897787692 modified "2023-10-16" @default.
• W2897787692 title "Prothrombin complex concentrate versus placebo, no intervention, or other interventions in critically bleeding patients associated with oral anticoagulant administration: a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis" @default.
• W2897787692 cites W1563799380 @default.
• W2897787692 cites W1580911778 @default.
• W2897787692 cites W1596397105 @default.
• W2897787692 cites W1641613989 @default.
• W2897787692 cites W1714980748 @default.
• W2897787692 cites W1856855783 @default.
• W2897787692 cites W1928346723 @default.
• W2897787692 cites W1955113749 @default.
• W2897787692 cites W1964502734 @default.
• W2897787692 cites W1966921182 @default.
• W2897787692 cites W1967959895 @default.
• W2897787692 cites W1971441597 @default.
• W2897787692 cites W1971785694 @default.
• W2897787692 cites W1977733462 @default.
• W2897787692 cites W1983429041 @default.
• W2897787692 cites W1989782940 @default.
• W2897787692 cites W1994402165 @default.
• W2897787692 cites W2003701152 @default.
• W2897787692 cites W2007301755 @default.
• W2897787692 cites W2011932878 @default.
• W2897787692 cites W2022008771 @default.
• W2897787692 cites W2030346622 @default.
• W2897787692 cites W2034607173 @default.
• W2897787692 cites W2038708044 @default.
• W2897787692 cites W2048269822 @default.
• W2897787692 cites W2049852456 @default.
• W2897787692 cites W2055469806 @default.
• W2897787692 cites W2064817897 @default.
• W2897787692 cites W2065193471 @default.
• W2897787692 cites W2065267852 @default.
• W2897787692 cites W2065384164 @default.
• W2897787692 cites W2068476516 @default.
• W2897787692 cites W2069353376 @default.
• W2897787692 cites W2080772702 @default.
• W2897787692 cites W2088707870 @default.
• W2897787692 cites W2091494376 @default.
• W2897787692 cites W2094585602 @default.
• W2897787692 cites W2097409354 @default.
• W2897787692 cites W2097687553 @default.
• W2897787692 cites W2099409915 @default.
• W2897787692 cites W2102493362 @default.
• W2897787692 cites W2102719739 @default.
• W2897787692 cites W2103410254 @default.
• W2897787692 cites W2105908213 @default.
• W2897787692 cites W2105938731 @default.
• W2897787692 cites W2108991533 @default.
• W2897787692 cites W2109450134 @default.
• W2897787692 cites W2110970000 @default.
• W2897787692 cites W2117294447 @default.
• W2897787692 cites W2118340301 @default.
• W2897787692 cites W2126603651 @default.
• W2897787692 cites W2127765911 @default.
• W2897787692 cites W2130487729 @default.
• W2897787692 cites W2134338262 @default.
• W2897787692 cites W2142187440 @default.
• W2897787692 cites W2142917088 @default.
• W2897787692 cites W2143829405 @default.
• W2897787692 cites W2145899514 @default.
• W2897787692 cites W2152647843 @default.
• W2897787692 cites W2154438850 @default.
• W2897787692 cites W2157823046 @default.
• W2897787692 cites W2165010366 @default.
• W2897787692 cites W2166866093 @default.
• W2897787692 cites W2170952317 @default.
• W2897787692 cites W2174386486 @default.
• W2897787692 cites W2193505501 @default.
• W2897787692 cites W2201013905 @default.
• W2897787692 cites W2209358119 @default.
• W2897787692 cites W2221303260 @default.
• W2897787692 cites W2259135635 @default.
• W2897787692 cites W2282129983 @default.
• W2897787692 cites W2284447120 @default.
• W2897787692 cites W2323559086 @default.
• W2897787692 cites W2330133051 @default.
• W2897787692 cites W2338123562 @default.
• W2897787692 cites W2345602403 @default.
• W2897787692 cites W2472040764 @default.
• W2897787692 cites W2481569543 @default.
• W2897787692 cites W2508934593 @default.
• W2897787692 cites W2514338974 @default.
• W2897787692 cites W2517326343 @default.
• W2897787692 cites W2519385404 @default.
• W2897787692 cites W2531262358 @default.
• W2897787692 cites W2549559667 @default.
• W2897787692 cites W2557238897 @default.
• W2897787692 cites W2562461813 @default.
• W2897787692 cites W2564725497 @default.
• W2897787692 cites W256873987 @default.
• W2897787692 cites W2575092362 @default.

• next