FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897788002> ?p ?o ?g. }

• W2897788002 endingPage "7749" @default.
• W2897788002 startingPage "7737" @default.
• W2897788002 abstract "Nanocarriers can be translocated to the peripheral region of tumor tissues through the well-known enhanced permeability and retention effects. However, a high dose of nanocarriers need to be injected due to the low delivery efficiency of nanocarriers, which can also increase the side effects of off-targeted nanocarriers in normal tissues. It was demonstrated that on-demand drug release from tumor-targeted nanocarriers can reduce the effective dosage of anti-cancer drugs by rapidly increasing the local drug concentration in the tumor tissue. Here we report a near-infrared (NIR) photodynamic method to trigger drug release from tumor-targeted polymer nanoparticles via reactive oxygen species (ROS)-mediated polymer degradation. Paclitaxel and silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) were co-encapsulated as an anti-cancer drug and photosensitizer, respectively, within biotin-decorated poly(ethylene glycol)-polythioketal micelles. Upon NIR light illumination under the maximum permissible exposure level, the photoexcited naphthalocyanine generated ROS cleaved the thioketal groups in the micelles to release the encapsulated paclitaxel. The photodynamically-induced release of paclitaxel dramatically reduced the half maximal inhibitory concentration of paclitaxel by 39.9-fold and eliminated lung adenocarcinoma at a concentration an order of magnitude smaller than its maximum tolerated dosage. Even under a simulated deep tissue condition with a tissue-like phantom, the NIR light-illuminated micelles exhibited a high level of cytotoxicity against the tumor cells and efficiently suppressed tumor growth. Our study demonstrates that photodynamic polymer degradation is an effective means to improve the anticancer drug efficacy of tumor-targeted micelles." @default.
• W2897788002 created "2018-10-26" @default.
• W2897788002 creator A5027456707 @default.
• W2897788002 creator A5041832027 @default.
• W2897788002 creator A5045941705 @default.
• W2897788002 creator A5060810288 @default.
• W2897788002 creator A5090961452 @default.
• W2897788002 date "2018-01-01" @default.
• W2897788002 modified "2023-10-08" @default.
• W2897788002 title "Cancer-targeted reactive oxygen species-degradable polymer nanoparticles for near infrared light-induced drug release" @default.
• W2897788002 cites W1522280384 @default.
• W2897788002 cites W1771974095 @default.
• W2897788002 cites W1833276860 @default.
• W2897788002 cites W1894195601 @default.
• W2897788002 cites W1900658750 @default.
• W2897788002 cites W1903778810 @default.
• W2897788002 cites W1946971315 @default.
• W2897788002 cites W1966637837 @default.
• W2897788002 cites W1970997677 @default.
• W2897788002 cites W1975823196 @default.
• W2897788002 cites W1990636775 @default.
• W2897788002 cites W1991525295 @default.
• W2897788002 cites W2003160941 @default.
• W2897788002 cites W2005334224 @default.
• W2897788002 cites W2007553857 @default.
• W2897788002 cites W2017054309 @default.
• W2897788002 cites W2017342990 @default.
• W2897788002 cites W2018277210 @default.
• W2897788002 cites W2025374137 @default.
• W2897788002 cites W2041104977 @default.
• W2897788002 cites W2041685752 @default.
• W2897788002 cites W2055244270 @default.
• W2897788002 cites W2066796083 @default.
• W2897788002 cites W2069717224 @default.
• W2897788002 cites W2073529185 @default.
• W2897788002 cites W2075960393 @default.
• W2897788002 cites W2080241938 @default.
• W2897788002 cites W2087339674 @default.
• W2897788002 cites W2090797725 @default.
• W2897788002 cites W2090932303 @default.
• W2897788002 cites W2109306300 @default.
• W2897788002 cites W2112927879 @default.
• W2897788002 cites W2123103156 @default.
• W2897788002 cites W2130166533 @default.
• W2897788002 cites W2131888732 @default.
• W2897788002 cites W2143463421 @default.
• W2897788002 cites W2152429732 @default.
• W2897788002 cites W2158303916 @default.
• W2897788002 cites W2166479549 @default.
• W2897788002 cites W2167011671 @default.
• W2897788002 cites W2207865396 @default.
• W2897788002 cites W2223635015 @default.
• W2897788002 cites W2297565643 @default.
• W2897788002 cites W2341002190 @default.
• W2897788002 cites W2343061763 @default.
• W2897788002 cites W2344252956 @default.
• W2897788002 cites W2432913624 @default.
• W2897788002 cites W2462308201 @default.
• W2897788002 cites W2552930736 @default.
• W2897788002 cites W2575428389 @default.
• W2897788002 cites W2582351074 @default.
• W2897788002 cites W2589055971 @default.
• W2897788002 cites W2766673373 @default.
• W2897788002 cites W2769964316 @default.
• W2897788002 cites W2774932143 @default.
• W2897788002 cites W2885507526 @default.
• W2897788002 cites W2950704792 @default.
• W2897788002 cites W992184737 @default.
• W2897788002 doi "https://doi.org/10.1039/c8tb02323a" @default.
• W2897788002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32254896" @default.
• W2897788002 hasPublicationYear "2018" @default.
• W2897788002 type Work @default.
• W2897788002 sameAs 2897788002 @default.
• W2897788002 citedByCount "19" @default.
• W2897788002 countsByYear W28977880022019 @default.
• W2897788002 countsByYear W28977880022020 @default.
• W2897788002 countsByYear W28977880022021 @default.
• W2897788002 countsByYear W28977880022022 @default.
• W2897788002 countsByYear W28977880022023 @default.
• W2897788002 crossrefType "journal-article" @default.
• W2897788002 hasAuthorship W2897788002A5027456707 @default.
• W2897788002 hasAuthorship W2897788002A5041832027 @default.
• W2897788002 hasAuthorship W2897788002A5045941705 @default.
• W2897788002 hasAuthorship W2897788002A5060810288 @default.
• W2897788002 hasAuthorship W2897788002A5090961452 @default.
• W2897788002 hasConcept C109316439 @default.
• W2897788002 hasConcept C11268172 @default.
• W2897788002 hasConcept C121608353 @default.
• W2897788002 hasConcept C12554922 @default.
• W2897788002 hasConcept C126322002 @default.
• W2897788002 hasConcept C13245373 @default.
• W2897788002 hasConcept C155672457 @default.
• W2897788002 hasConcept C171250308 @default.
• W2897788002 hasConcept C178790620 @default.
• W2897788002 hasConcept C18150654 @default.
• W2897788002 hasConcept C184651966 @default.
• W2897788002 hasConcept C185592680 @default.
• W2897788002 hasConcept C192562407 @default.

• next