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- W2897788243 abstract "Abstract Japan is one of the few rabies-free countries/territories which implement the policy of mandatory vaccination of domestic dogs. In order to assess the economic efficiency of such policy in reducing the economic burden of a future canine rabies outbreak in Japan, a benefit-cost analysis (BCA) was performed using probabilistic decision tree modelling. Input data derived from simulation results of published mathematical model, field investigation conducted by the authors at prefectural governments, literature review, international or Japanese database and empirical data of rabies outbreaks in other countries/territories. The current study revealed that the annual costs of implementing the current vaccination policy would be US$160,472,075 (90% prediction interval [PI]: $149,268,935 – 171,669,974). The economic burden of a potential canine rabies outbreak in Japan were estimated to be US$1,682,707 (90% PI: $1,180,289 – 2,249,283) under the current vaccination policy, while it would be US$5,019,093 (90% PI: $3,986,882 – 6,133,687) under hypothetical abolition of vaccination policy, which is 3-fold higher. Under a damage-avoided approach, the annual benefits of implementing the current vaccination policy in expected value were estimated to be US$85.75 (90% PI: $55.73 – 116.89). The benefit-cost ratio (BCR) was estimated to be 5.35 × 10 −7 (90% PI: 3.46 × 10 −7 – 7.37 × 10 −7 ), indicating that the implementation of the current policy is very economically inefficient for the purpose of reducing the economic burden of a potential canine rabies outbreak. In worse-case scenario analysis, the BCR would become above 1 (indicating economic efficiency) if the risk of rabies introduction increased to 0.04 corresponding to a level of risk where rabies would enter Japan in 26 years while the economic burden of a rabies outbreak under the abolition of vaccination policy increased to $7.53 billion. Best-case analysis further revealed that the economic efficiency of the current policy could be improved by decreasing the vaccination price charged to dog owners, relaxing the frequency of vaccination to every two to three years and implementing the policy on a smaller scale, e.g. only in targeted prefectures instead of the whole Japan." @default.
- W2897788243 created "2018-10-26" @default.
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- W2897788243 date "2018-10-19" @default.
- W2897788243 modified "2023-10-14" @default.
- W2897788243 title "Benefit-cost analysis of the policy of mandatory annual rabies vaccination of domestic dogs in rabies-free Japan" @default.
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- W2897788243 doi "https://doi.org/10.1101/448258" @default.
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