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• W2897790977 abstract "Protein interactions are usually determined by well-defined contact patterns. In this scenario, structuring of the interface is a prerequisite, which takes place prior or coupled to binding. Recent data, however, indicate plasticity of the templated folding pathway as well as considerable variations: polymorphism or dynamics in the bound-state. Conformational fluctuations in both cases are modulated by non-native, transient contacts, which complement suboptimal binding motifs to improve affinity. Here I discuss both templated folding and fuzzy binding mechanisms and propose a uniform scheme." @default.
• W2897790977 created "2018-10-26" @default.
• W2897790977 creator A5013000080 @default.
• W2897790977 date "2019-02-01" @default.
• W2897790977 modified "2023-10-03" @default.
• W2897790977 title "Fold or not to fold upon binding — does it really matter?" @default.
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• W2897790977 doi "https://doi.org/10.1016/j.sbi.2018.09.008" @default.
• W2897790977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30340123" @default.
• W2897790977 hasPublicationYear "2019" @default.
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