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• W2897792831 endingPage "1721" @default.
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• W2897792831 abstract "The Shaker-like family of voltage-gated K+ channels comprises four functionally independent gene subfamilies, Shaker (Kv1), Shab (Kv2), Shaw (Kv3), and Shal (Kv4), each of which regulates distinct aspects of neuronal excitability. Subfamily-specific assembly of tetrameric channels is mediated by the N-terminal T1 domain and segregates Kv1–4, allowing multiple channel types to function independently in the same cell. Typical Shaker-like Kv subunits can form functional channels as homotetramers, but a group of mammalian Kv2-related genes (Kv5.1, Kv6s, Kv8s, and Kv9s) encodes subunits that have a “silent” or “regulatory” phenotype characterized by T1 self-incompatibility. These channels are unable to form homotetramers, but instead heteromerize with Kv2.1 or Kv2.2 to diversify the functional properties of these delayed rectifiers. While T1 self-incompatibility predicts that these heterotetramers could contain up to two regulatory (R) subunits, experiments show a predominance of 3:1R stoichiometry in which heteromeric channels contain a single regulatory subunit. Substitution of the self-compatible Kv2.1 T1 domain into the regulatory subunit Kv6.4 does not alter the stoichiometry of Kv2.1:Kv6.4 heteromers. Here, to identify other channel structures that might be responsible for favoring the 3:1R stoichiometry, we compare the sequences of mammalian regulatory subunits to independently evolved regulatory subunits from cnidarians. The most widespread feature of regulatory subunits is the presence of atypical substitutions in the highly conserved consensus sequence of the intracellular S6 activation gate of the pore. We show that two amino acid substitutions in the S6 gate of the regulatory subunit Kv6.4 restrict the functional stoichiometry of Kv2.1:Kv6.4 to 3:1R by limiting the formation and function of 2:2R heteromers. We propose a two-step model for the evolution of the asymmetric 3:1R stoichiometry, which begins with evolution of self-incompatibility to establish the regulatory phenotype, followed by drift of the activation gate consensus sequence under relaxed selection to limit stoichiometry to 3:1R." @default.
• W2897792831 created "2018-10-26" @default.
• W2897792831 creator A5007662018 @default.
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• W2897792831 date "2018-10-15" @default.
• W2897792831 modified "2023-10-14" @default.
• W2897792831 title "The S6 gate in regulatory Kv6 subunits restricts heteromeric K+ channel stoichiometry" @default.
• W2897792831 cites W1646522829 @default.
• W2897792831 cites W1790243440 @default.
• W2897792831 cites W1794934403 @default.
• W2897792831 cites W1868485233 @default.
• W2897792831 cites W1925830464 @default.
• W2897792831 cites W1929540261 @default.
• W2897792831 cites W1937739983 @default.
• W2897792831 cites W1959918077 @default.
• W2897792831 cites W1968128767 @default.
• W2897792831 cites W1975424106 @default.
• W2897792831 cites W1977988255 @default.
• W2897792831 cites W1980187628 @default.
• W2897792831 cites W1983231052 @default.
• W2897792831 cites W1983519301 @default.
• W2897792831 cites W1983520523 @default.
• W2897792831 cites W1984704872 @default.
• W2897792831 cites W1986668651 @default.
• W2897792831 cites W1988505512 @default.
• W2897792831 cites W1992745080 @default.
• W2897792831 cites W1994858472 @default.
• W2897792831 cites W1997293666 @default.
• W2897792831 cites W2006307429 @default.
• W2897792831 cites W2008522479 @default.
• W2897792831 cites W2011301782 @default.
• W2897792831 cites W2011546287 @default.
• W2897792831 cites W2011565078 @default.
• W2897792831 cites W2012217125 @default.
• W2897792831 cites W2012422753 @default.
• W2897792831 cites W2013909800 @default.
• W2897792831 cites W2015113067 @default.
• W2897792831 cites W2027408247 @default.
• W2897792831 cites W2029259174 @default.
• W2897792831 cites W2029667189 @default.
• W2897792831 cites W2031426087 @default.
• W2897792831 cites W2032734987 @default.
• W2897792831 cites W2034132958 @default.
• W2897792831 cites W2038894306 @default.
• W2897792831 cites W2044341713 @default.
• W2897792831 cites W2046560280 @default.
• W2897792831 cites W2056776817 @default.
• W2897792831 cites W2057649963 @default.
• W2897792831 cites W2065246556 @default.
• W2897792831 cites W2066681343 @default.
• W2897792831 cites W2070818613 @default.
• W2897792831 cites W2074270070 @default.
• W2897792831 cites W2078277943 @default.
• W2897792831 cites W2079500691 @default.
• W2897792831 cites W2079747449 @default.
• W2897792831 cites W2079762354 @default.
• W2897792831 cites W2082311924 @default.
• W2897792831 cites W2083128912 @default.
• W2897792831 cites W2088734315 @default.
• W2897792831 cites W2094813259 @default.
• W2897792831 cites W2097360436 @default.
• W2897792831 cites W2098813499 @default.
• W2897792831 cites W2099949778 @default.
• W2897792831 cites W2104129019 @default.
• W2897792831 cites W2113412887 @default.
• W2897792831 cites W2114520383 @default.
• W2897792831 cites W2120772351 @default.
• W2897792831 cites W2121501171 @default.
• W2897792831 cites W2128420761 @default.
• W2897792831 cites W2134351637 @default.
• W2897792831 cites W2137002627 @default.
• W2897792831 cites W2141650637 @default.
• W2897792831 cites W2150981663 @default.
• W2897792831 cites W2151454863 @default.
• W2897792831 cites W2151525286 @default.
• W2897792831 cites W2152333325 @default.
• W2897792831 cites W2157189708 @default.
• W2897792831 cites W2158266834 @default.
• W2897792831 cites W2163312887 @default.
• W2897792831 cites W2163598778 @default.
• W2897792831 cites W2164829352 @default.
• W2897792831 cites W2166599924 @default.
• W2897792831 cites W2170150201 @default.
• W2897792831 cites W2181527086 @default.
• W2897792831 cites W2282441615 @default.
• W2897792831 cites W2311203695 @default.
• W2897792831 cites W2399661126 @default.
• W2897792831 cites W2418361432 @default.
• W2897792831 cites W2530766428 @default.

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