FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897793507> ?p ?o ?g. }

• W2897793507 abstract "Abstract Chronic myelomonocytic leukemia (CMML) is an entity of myelodysplastic syndrome/myeloproliferative neoplasm. Although CMML can be cured with allogeneic stem cell transplantation, its prognosis is generally very poor due to the limited efficacy of chemotherapy and to the patient’s age, which is usually not eligible for transplantation. Comprehensive analysis of CMML pathophysiology and the development of therapeutic agents have been limited partly due to the lack of cell lines in CMML and the limited developments of mouse models. After successfully establishing patient’s derived disease-specific induced pluripotent stem cells (iPSCs) derived from a patient with CMML, we utilized these CMML-iPSCs to achieve hematopoietic re-differentiation in vitro , created a humanized CMML mouse model via teratomas, and developed a drug-testing system. The clinical characteristics of CMML were recapitulated following hematopoietic re-differentiation in vitro and a humanized CMML mouse model in vivo . The drug-testing system using CMML-iPSCs identified a MEK inhibitor, a Ras inhibitor, and liposomal clodronate as potential drugs for treating CMML. Clodronate is a drug commonly used as a bisphosphonate for osteoporosis. In this study, the liposomalization of clodronate enhanced its effectiveness in these assays, suggesting that this variation of clodronate may be adopted as a repositioned drug for CMML therapy." @default.
• W2897793507 created "2018-10-26" @default.
• W2897793507 creator A5019858381 @default.
• W2897793507 creator A5019953695 @default.
• W2897793507 creator A5024179981 @default.
• W2897793507 creator A5030021970 @default.
• W2897793507 creator A5032378106 @default.
• W2897793507 creator A5035622718 @default.
• W2897793507 creator A5036588428 @default.
• W2897793507 creator A5055622415 @default.
• W2897793507 creator A5059937255 @default.
• W2897793507 creator A5065889724 @default.
• W2897793507 creator A5068891653 @default.
• W2897793507 creator A5073075039 @default.
• W2897793507 creator A5080083757 @default.
• W2897793507 creator A5081750005 @default.
• W2897793507 creator A5085709435 @default.
• W2897793507 creator A5091299917 @default.
• W2897793507 date "2018-10-26" @default.
• W2897793507 modified "2023-10-17" @default.
• W2897793507 title "Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate" @default.
• W2897793507 cites W1605294605 @default.
• W2897793507 cites W1928825406 @default.
• W2897793507 cites W1987111575 @default.
• W2897793507 cites W1990334823 @default.
• W2897793507 cites W2005744447 @default.
• W2897793507 cites W2025762987 @default.
• W2897793507 cites W2043457504 @default.
• W2897793507 cites W2047658414 @default.
• W2897793507 cites W2049662718 @default.
• W2897793507 cites W2056589782 @default.
• W2897793507 cites W2058837304 @default.
• W2897793507 cites W2065786649 @default.
• W2897793507 cites W2074191990 @default.
• W2897793507 cites W2095041841 @default.
• W2897793507 cites W2099313405 @default.
• W2897793507 cites W2138977668 @default.
• W2897793507 cites W2149089431 @default.
• W2897793507 cites W2161315819 @default.
• W2897793507 cites W2339658711 @default.
• W2897793507 cites W2572857985 @default.
• W2897793507 cites W2588979246 @default.
• W2897793507 cites W2621241527 @default.
• W2897793507 cites W2626315581 @default.
• W2897793507 cites W2674575612 @default.
• W2897793507 cites W2731190547 @default.
• W2897793507 cites W2757858576 @default.
• W2897793507 cites W2788733333 @default.
• W2897793507 cites W2805039397 @default.
• W2897793507 doi "https://doi.org/10.1038/s41598-018-34193-1" @default.
• W2897793507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203784" @default.
• W2897793507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30367142" @default.
• W2897793507 hasPublicationYear "2018" @default.
• W2897793507 type Work @default.
• W2897793507 sameAs 2897793507 @default.
• W2897793507 citedByCount "24" @default.
• W2897793507 countsByYear W28977935072019 @default.
• W2897793507 countsByYear W28977935072020 @default.
• W2897793507 countsByYear W28977935072021 @default.
• W2897793507 countsByYear W28977935072022 @default.
• W2897793507 countsByYear W28977935072023 @default.
• W2897793507 crossrefType "journal-article" @default.
• W2897793507 hasAuthorship W2897793507A5019858381 @default.
• W2897793507 hasAuthorship W2897793507A5019953695 @default.
• W2897793507 hasAuthorship W2897793507A5024179981 @default.
• W2897793507 hasAuthorship W2897793507A5030021970 @default.
• W2897793507 hasAuthorship W2897793507A5032378106 @default.
• W2897793507 hasAuthorship W2897793507A5035622718 @default.
• W2897793507 hasAuthorship W2897793507A5036588428 @default.
• W2897793507 hasAuthorship W2897793507A5055622415 @default.
• W2897793507 hasAuthorship W2897793507A5059937255 @default.
• W2897793507 hasAuthorship W2897793507A5065889724 @default.
• W2897793507 hasAuthorship W2897793507A5068891653 @default.
• W2897793507 hasAuthorship W2897793507A5073075039 @default.
• W2897793507 hasAuthorship W2897793507A5080083757 @default.
• W2897793507 hasAuthorship W2897793507A5081750005 @default.
• W2897793507 hasAuthorship W2897793507A5085709435 @default.
• W2897793507 hasAuthorship W2897793507A5091299917 @default.
• W2897793507 hasBestOaLocation W28977935071 @default.
• W2897793507 hasConcept C104317684 @default.
• W2897793507 hasConcept C107459253 @default.
• W2897793507 hasConcept C109159458 @default.
• W2897793507 hasConcept C126322002 @default.
• W2897793507 hasConcept C145103041 @default.
• W2897793507 hasConcept C150903083 @default.
• W2897793507 hasConcept C203014093 @default.
• W2897793507 hasConcept C207001950 @default.
• W2897793507 hasConcept C2777928532 @default.
• W2897793507 hasConcept C2778461978 @default.
• W2897793507 hasConcept C2780007613 @default.
• W2897793507 hasConcept C2780035454 @default.
• W2897793507 hasConcept C2780817109 @default.
• W2897793507 hasConcept C28328180 @default.
• W2897793507 hasConcept C2911091166 @default.
• W2897793507 hasConcept C502942594 @default.
• W2897793507 hasConcept C54355233 @default.
• W2897793507 hasConcept C55493867 @default.
• W2897793507 hasConcept C64903051 @default.
• W2897793507 hasConcept C71924100 @default.
• W2897793507 hasConcept C86803240 @default.

• next