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• W2897794787 abstract "There are huge variations in life-stage- and species-specific sensitivities among the fishes to the exposure with metals; however, the physiological mechanisms underlying these differences are not well understood to date. This study revealed significant life-stage-specific (larval, swim-up, and juvenile) and species-specific differences between two evolutionary distant species of fishes, rainbow trout (Oncorhynchus mykiss) and white sturgeon (Acipenser transmontanus), following acute exposures to Cd. Although the 96 h LC50 of Cd was similar in both species at the larval stage, trout demonstrated an increased sensitivity to Cd at later life stages as compared to sturgeon. Moreover, exposure to Cd disrupted calcium (Ca) uptake and whole body Ca levels in trout by a greater degree relative to that in sturgeon regardless of life stage. Finally, white sturgeon demonstrated a lower affinity for Cd uptake relative to the more sensitive rainbow trout. This infers a differential nature of the interaction between Cd and Ca transport pathways in the two species and partially explains the differences in Cd sensitivity between rainbow trout and white sturgeon described previously. Overall, our results suggest that species- and life-stage-specific differences in sensitivity to waterborne Cd in fish are likely a function of the interplay between Cd uptake and Cd-induced disruption of Ca homeostasis." @default.
• W2897794787 created "2018-10-26" @default.
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• W2897794787 date "2018-10-16" @default.
• W2897794787 modified "2023-10-16" @default.
• W2897794787 title "Investigating the Role of Ionoregulatory Processes in the Species- and Life-Stage-Specific Differences in Sensitivity of Rainbow Trout and White Sturgeon to Cadmium" @default.
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• W2897794787 doi "https://doi.org/10.1021/acs.est.8b04828" @default.
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