FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897797766> ?p ?o ?g. }

• W2897797766 abstract "In 1988 two seminal studies were published, both instigating controversy. One concluded that the energy needs of activated neural tissue are minimal, being fulfilled via the glycolytic pathway alone, a conclusion based on the observation that neural activation increased glucose consumption not accompanied by a corresponding increase in oxygen consumption (Fox et al.). The second demonstrated that neural tissue function can be supported exclusively by lactate as the energy substrate (Schurr et al.). While both studies continue to have their supporters and detractors, the present review attempts to clarify the issues responsible for the persistence of the controversies they have provoked and offer a possible rationalization. The concept that lactate, not pyruvate, is the end-product of glycolysis, both aerobically and anaerobically, and the real mitochondrial oxidative substrate has gained a greater acceptance over the years. The idea of glycolysis as the sole ATP supplier for neural activation (glucose → lactate + 2ATP) continues to be controversial. Lactate oxidative utilization by activated neural tissue could explain the mismatch between glucose and oxygen consumption and resolve the existing disagreements among users of imaging methods to measure the metabolic rates of the two energy metabolic substrates. The postulate that the energy necessary for active neural tissue is supplied by glycolysis alone stems from the original aerobic glycolysis paradigm. Accordingly, glucose consumption is accompanied by oxygen consumption at 1 to 6 ratio. Since Fox and colleagues observed only a minimal if nonexistent oxygen consumption compared to glucose consumption, their conclusion make sense. Nevertheless, considering a) the shift in the paradigm of glycolysis (glucose → lactate; lactate + O2 + mitochondria → pyruvate → TCA cycle → CO2 + H2O + 17ATP); b) that one mole of lactate oxidation requires only 50% of the amount of oxygen necessary for the oxidation of one mole of glucose and c) that lactate, as a mitochondrial substrate, is over eight times more efficient at ATP production than glucose as a glycolytic substrate, suggest that future studies of cerebral metabolic rates of activated neural tissue should include along with the measurements of CMRO2 and CMRglucose the measurement of CMRlactate." @default.
• W2897797766 created "2018-10-26" @default.
• W2897797766 creator A5029976912 @default.
• W2897797766 date "2018-10-10" @default.
• W2897797766 modified "2023-10-16" @default.
• W2897797766 title "Glycolysis Paradigm Shift Dictates a Reevaluation of Glucose and Oxygen Metabolic Rates of Activated Neural Tissue" @default.
• W2897797766 cites W1205094827 @default.
• W2897797766 cites W154424764 @default.
• W2897797766 cites W1556795561 @default.
• W2897797766 cites W1772857860 @default.
• W2897797766 cites W1819285150 @default.
• W2897797766 cites W1933882513 @default.
• W2897797766 cites W1957471014 @default.
• W2897797766 cites W1963852341 @default.
• W2897797766 cites W1964640968 @default.
• W2897797766 cites W1964844927 @default.
• W2897797766 cites W1966382524 @default.
• W2897797766 cites W1966886729 @default.
• W2897797766 cites W1967009686 @default.
• W2897797766 cites W1969826942 @default.
• W2897797766 cites W1971418593 @default.
• W2897797766 cites W1975661602 @default.
• W2897797766 cites W1976613901 @default.
• W2897797766 cites W1976833922 @default.
• W2897797766 cites W1978617737 @default.
• W2897797766 cites W1979701597 @default.
• W2897797766 cites W1979753452 @default.
• W2897797766 cites W1981319871 @default.
• W2897797766 cites W1988535726 @default.
• W2897797766 cites W1988714133 @default.
• W2897797766 cites W1993303421 @default.
• W2897797766 cites W2000061494 @default.
• W2897797766 cites W2005122657 @default.
• W2897797766 cites W2006383602 @default.
• W2897797766 cites W2010297672 @default.
• W2897797766 cites W2011262365 @default.
• W2897797766 cites W2011835237 @default.
• W2897797766 cites W2013821356 @default.
• W2897797766 cites W2013886277 @default.
• W2897797766 cites W2017790389 @default.
• W2897797766 cites W2024564250 @default.
• W2897797766 cites W2024773521 @default.
• W2897797766 cites W2025935630 @default.
• W2897797766 cites W2026612464 @default.
• W2897797766 cites W2027226224 @default.
• W2897797766 cites W2027671847 @default.
• W2897797766 cites W2032163981 @default.
• W2897797766 cites W2032802983 @default.
• W2897797766 cites W2032878973 @default.
• W2897797766 cites W2034004233 @default.
• W2897797766 cites W2041277840 @default.
• W2897797766 cites W2045147785 @default.
• W2897797766 cites W2046194682 @default.
• W2897797766 cites W2046806927 @default.
• W2897797766 cites W2048453304 @default.
• W2897797766 cites W2051886358 @default.
• W2897797766 cites W2053444468 @default.
• W2897797766 cites W2055433881 @default.
• W2897797766 cites W2056934253 @default.
• W2897797766 cites W2058698074 @default.
• W2897797766 cites W2059888980 @default.
• W2897797766 cites W2061814167 @default.
• W2897797766 cites W2063932219 @default.
• W2897797766 cites W2066349475 @default.
• W2897797766 cites W2067548955 @default.
• W2897797766 cites W2067990182 @default.
• W2897797766 cites W2069987358 @default.
• W2897797766 cites W2071714163 @default.
• W2897797766 cites W2073781183 @default.
• W2897797766 cites W2078241081 @default.
• W2897797766 cites W2083556553 @default.
• W2897797766 cites W2085509818 @default.
• W2897797766 cites W2090306035 @default.
• W2897797766 cites W2091444961 @default.
• W2897797766 cites W2092195115 @default.
• W2897797766 cites W2092635505 @default.
• W2897797766 cites W2092969356 @default.
• W2897797766 cites W2094106149 @default.
• W2897797766 cites W2094633691 @default.
• W2897797766 cites W2095285518 @default.
• W2897797766 cites W2097975739 @default.
• W2897797766 cites W2098685543 @default.
• W2897797766 cites W2100918961 @default.
• W2897797766 cites W2101969014 @default.
• W2897797766 cites W2107450931 @default.
• W2897797766 cites W2108933333 @default.
• W2897797766 cites W2111636333 @default.
• W2897797766 cites W2112994046 @default.
• W2897797766 cites W2120238759 @default.
• W2897797766 cites W2121552348 @default.
• W2897797766 cites W2127561960 @default.
• W2897797766 cites W2134333026 @default.
• W2897797766 cites W2139155172 @default.
• W2897797766 cites W2142522488 @default.
• W2897797766 cites W2142884473 @default.
• W2897797766 cites W2143647842 @default.
• W2897797766 cites W2151818004 @default.
• W2897797766 cites W2153022805 @default.
• W2897797766 cites W2155381968 @default.
• W2897797766 cites W2157526951 @default.

• next