FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897798868> ?p ?o ?g. }

• W2897798868 endingPage "1002" @default.
• W2897798868 startingPage "996" @default.
• W2897798868 abstract "Recently, a large number of studies have shown that circular RNA (circRNA) is involved in the development and progression of human cancer. However, its role in triple-negative breast cancer (TNBC) remains largely unknown. In this study, a novel circRNA, circ-UBAP2 (hsa_circ_0001846), was shown to be markedly upregulated in TNBC. Moreover, high circ-UBAP2 expression was closely associated with larger tumour size (p = 0.003), advanced TNM stage (p = 0.005), lymph node metastasis (p = 0.002), and unfavourable prognosis (p = 0.0256). Functionally, lentivirus-mediated stable knockdown of circ-UBAP2 dramatically weakened the ability of TNBC cells to proliferate and migrate and induced apoptosis in vitro and in vivo. Regarding the mechanism, we found that circ-UBAP2 was mainly observed in the cytoplasm and was capable of sponging miRNA-661 to increase the expression of the oncogene MTA1. Additionally, silencing of miRNA-661 or overexpression of MTA1 could partially rescue the attenuated malignant phenotype caused by circ-UBAP2 knockdown. Taken together, our data reveal that circ-UBAP2 plays a vital regulatory role in TNBC via the miR-661/MTA1 axis and may serve as a promising therapeutic target for TNBC patients." @default.
• W2897798868 created "2018-10-26" @default.
• W2897798868 creator A5014942240 @default.
• W2897798868 creator A5040721399 @default.
• W2897798868 creator A5043799729 @default.
• W2897798868 creator A5048089805 @default.
• W2897798868 creator A5048383602 @default.
• W2897798868 creator A5070812231 @default.
• W2897798868 creator A5078946566 @default.
• W2897798868 creator A5084461414 @default.
• W2897798868 creator A5085314218 @default.
• W2897798868 creator A5091000947 @default.
• W2897798868 date "2018-11-01" @default.
• W2897798868 modified "2023-09-27" @default.
• W2897798868 title "Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway" @default.
• W2897798868 cites W1969346276 @default.
• W2897798868 cites W1971761901 @default.
• W2897798868 cites W1991082489 @default.
• W2897798868 cites W2058835062 @default.
• W2897798868 cites W2064165694 @default.
• W2897798868 cites W2107387177 @default.
• W2897798868 cites W2130687298 @default.
• W2897798868 cites W2174166388 @default.
• W2897798868 cites W2210577735 @default.
• W2897798868 cites W2562634188 @default.
• W2897798868 cites W2563351911 @default.
• W2897798868 cites W2604165590 @default.
• W2897798868 cites W2616072553 @default.
• W2897798868 cites W2754487734 @default.
• W2897798868 cites W2764294957 @default.
• W2897798868 cites W2766969050 @default.
• W2897798868 cites W2789403589 @default.
• W2897798868 cites W2790953059 @default.
• W2897798868 cites W2795546864 @default.
• W2897798868 cites W2795917193 @default.
• W2897798868 cites W2798204307 @default.
• W2897798868 cites W2799569089 @default.
• W2897798868 cites W2800620450 @default.
• W2897798868 cites W2801831706 @default.
• W2897798868 cites W2805468119 @default.
• W2897798868 cites W2808219623 @default.
• W2897798868 cites W2808355442 @default.
• W2897798868 cites W2809253724 @default.
• W2897798868 cites W2849052994 @default.
• W2897798868 cites W2883062882 @default.
• W2897798868 cites W2884692871 @default.
• W2897798868 cites W2885229294 @default.
• W2897798868 cites W2886387652 @default.
• W2897798868 cites W2888149157 @default.
• W2897798868 cites W2891412523 @default.
• W2897798868 doi "https://doi.org/10.1016/j.bbrc.2018.10.026" @default.
• W2897798868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30314706" @default.
• W2897798868 hasPublicationYear "2018" @default.
• W2897798868 type Work @default.
• W2897798868 sameAs 2897798868 @default.
• W2897798868 citedByCount "80" @default.
• W2897798868 countsByYear W28977988682019 @default.
• W2897798868 countsByYear W28977988682020 @default.
• W2897798868 countsByYear W28977988682021 @default.
• W2897798868 countsByYear W28977988682022 @default.
• W2897798868 countsByYear W28977988682023 @default.
• W2897798868 crossrefType "journal-article" @default.
• W2897798868 hasAuthorship W2897798868A5014942240 @default.
• W2897798868 hasAuthorship W2897798868A5040721399 @default.
• W2897798868 hasAuthorship W2897798868A5043799729 @default.
• W2897798868 hasAuthorship W2897798868A5048089805 @default.
• W2897798868 hasAuthorship W2897798868A5048383602 @default.
• W2897798868 hasAuthorship W2897798868A5070812231 @default.
• W2897798868 hasAuthorship W2897798868A5078946566 @default.
• W2897798868 hasAuthorship W2897798868A5084461414 @default.
• W2897798868 hasAuthorship W2897798868A5085314218 @default.
• W2897798868 hasAuthorship W2897798868A5091000947 @default.
• W2897798868 hasConcept C104317684 @default.
• W2897798868 hasConcept C119056186 @default.
• W2897798868 hasConcept C121608353 @default.
• W2897798868 hasConcept C126322002 @default.
• W2897798868 hasConcept C127561419 @default.
• W2897798868 hasConcept C145059251 @default.
• W2897798868 hasConcept C173396325 @default.
• W2897798868 hasConcept C190283241 @default.
• W2897798868 hasConcept C2780110267 @default.
• W2897798868 hasConcept C2781018059 @default.
• W2897798868 hasConcept C29537977 @default.
• W2897798868 hasConcept C502942594 @default.
• W2897798868 hasConcept C530470458 @default.
• W2897798868 hasConcept C54355233 @default.
• W2897798868 hasConcept C71924100 @default.
• W2897798868 hasConcept C86803240 @default.
• W2897798868 hasConceptScore W2897798868C104317684 @default.
• W2897798868 hasConceptScore W2897798868C119056186 @default.
• W2897798868 hasConceptScore W2897798868C121608353 @default.
• W2897798868 hasConceptScore W2897798868C126322002 @default.
• W2897798868 hasConceptScore W2897798868C127561419 @default.
• W2897798868 hasConceptScore W2897798868C145059251 @default.
• W2897798868 hasConceptScore W2897798868C173396325 @default.
• W2897798868 hasConceptScore W2897798868C190283241 @default.
• W2897798868 hasConceptScore W2897798868C2780110267 @default.
• W2897798868 hasConceptScore W2897798868C2781018059 @default.

• next