FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897801044> ?p ?o ?g. }

• W2897801044 endingPage "709" @default.
• W2897801044 startingPage "703" @default.
• W2897801044 abstract "Genotoxic effects of nanomaterials (NMs) have been controversially reported in literature, and the mode of action (MoA) via DNA oxidation is cited as the main damage caused by them. Evidence of nano-silver as a crosslinker has been previously reported by the present research team in an in vivo fish genotoxicity study. Thus, aiming to confirm the evidence about NMs as crosslinker agent, the present investigation elucidated the genotoxic potential of NMs and their genotoxic MoA through in vitro assay with RTG-2 cells line (rainbow trout gonadal) by exposure to nano-silver (PVP-coated) and nano-titanium. The types and levels of DNA damage were assessed by the Comet assay (standard alkaline, hOGG1-modified alkaline, and two crosslink-modified alkaline versions). It was demonstrated that the use of the standard alkaline Comet assay alone may inaccurately predict the genotoxicity of NMs since oxidative and crosslink DNA damages were also verified in RTG-2 cells when assessed by the modified versions of the alkaline protocol. More importantly, it was confirmed that both nano-silver and nano-titanium acted as DNA-protein crosslinkers through the Comet assay version with proteinase K. As both nano-silver and nano-titanium present a great risk to aquatic life, these findings reinforce the need of genotoxicity testing strategies that encompass the assessment of different types of DNA damage, in order to ensure an accurate prediction of the genotoxic potential of NMs." @default.
• W2897801044 created "2018-10-26" @default.
• W2897801044 creator A5006217021 @default.
• W2897801044 creator A5029541903 @default.
• W2897801044 creator A5032771923 @default.
• W2897801044 creator A5040025033 @default.
• W2897801044 creator A5049888685 @default.
• W2897801044 creator A5078925223 @default.
• W2897801044 date "2019-01-01" @default.
• W2897801044 modified "2023-10-01" @default.
• W2897801044 title "Nanomaterials induce DNA-protein crosslink and DNA oxidation: A mechanistic study with RTG-2 fish cell line and Comet assay modifications" @default.
• W2897801044 cites W1136070835 @default.
• W2897801044 cites W1755978677 @default.
• W2897801044 cites W1959991859 @default.
• W2897801044 cites W1964529114 @default.
• W2897801044 cites W1966293661 @default.
• W2897801044 cites W1967189897 @default.
• W2897801044 cites W1970577073 @default.
• W2897801044 cites W1974508730 @default.
• W2897801044 cites W1995920508 @default.
• W2897801044 cites W1999235659 @default.
• W2897801044 cites W2008978315 @default.
• W2897801044 cites W2010276640 @default.
• W2897801044 cites W2015500565 @default.
• W2897801044 cites W2018221217 @default.
• W2897801044 cites W2019057425 @default.
• W2897801044 cites W2025808947 @default.
• W2897801044 cites W2036948210 @default.
• W2897801044 cites W2038211872 @default.
• W2897801044 cites W2046872563 @default.
• W2897801044 cites W2048959462 @default.
• W2897801044 cites W2050985306 @default.
• W2897801044 cites W2052178794 @default.
• W2897801044 cites W2078944426 @default.
• W2897801044 cites W2092036602 @default.
• W2897801044 cites W2102954760 @default.
• W2897801044 cites W2118050759 @default.
• W2897801044 cites W2125095236 @default.
• W2897801044 cites W2126902508 @default.
• W2897801044 cites W2138042860 @default.
• W2897801044 cites W2141237239 @default.
• W2897801044 cites W2147320907 @default.
• W2897801044 cites W2161940948 @default.
• W2897801044 cites W2161946971 @default.
• W2897801044 cites W2166679699 @default.
• W2897801044 cites W2171960659 @default.
• W2897801044 cites W2172101363 @default.
• W2897801044 cites W2301759200 @default.
• W2897801044 cites W2537901997 @default.
• W2897801044 cites W2559115147 @default.
• W2897801044 cites W2760736632 @default.
• W2897801044 cites W2763187509 @default.
• W2897801044 cites W2782429723 @default.
• W2897801044 doi "https://doi.org/10.1016/j.chemosphere.2018.10.118" @default.
• W2897801044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30347365" @default.
• W2897801044 hasPublicationYear "2019" @default.
• W2897801044 type Work @default.
• W2897801044 sameAs 2897801044 @default.
• W2897801044 citedByCount "22" @default.
• W2897801044 countsByYear W28978010442019 @default.
• W2897801044 countsByYear W28978010442020 @default.
• W2897801044 countsByYear W28978010442021 @default.
• W2897801044 countsByYear W28978010442022 @default.
• W2897801044 countsByYear W28978010442023 @default.
• W2897801044 crossrefType "journal-article" @default.
• W2897801044 hasAuthorship W2897801044A5006217021 @default.
• W2897801044 hasAuthorship W2897801044A5029541903 @default.
• W2897801044 hasAuthorship W2897801044A5032771923 @default.
• W2897801044 hasAuthorship W2897801044A5040025033 @default.
• W2897801044 hasAuthorship W2897801044A5049888685 @default.
• W2897801044 hasAuthorship W2897801044A5078925223 @default.
• W2897801044 hasConcept C107872376 @default.
• W2897801044 hasConcept C143425029 @default.
• W2897801044 hasConcept C153911025 @default.
• W2897801044 hasConcept C178790620 @default.
• W2897801044 hasConcept C185592680 @default.
• W2897801044 hasConcept C2778959862 @default.
• W2897801044 hasConcept C2780358455 @default.
• W2897801044 hasConcept C29730261 @default.
• W2897801044 hasConcept C552990157 @default.
• W2897801044 hasConcept C55493867 @default.
• W2897801044 hasConcept C86803240 @default.
• W2897801044 hasConceptScore W2897801044C107872376 @default.
• W2897801044 hasConceptScore W2897801044C143425029 @default.
• W2897801044 hasConceptScore W2897801044C153911025 @default.
• W2897801044 hasConceptScore W2897801044C178790620 @default.
• W2897801044 hasConceptScore W2897801044C185592680 @default.
• W2897801044 hasConceptScore W2897801044C2778959862 @default.
• W2897801044 hasConceptScore W2897801044C2780358455 @default.
• W2897801044 hasConceptScore W2897801044C29730261 @default.
• W2897801044 hasConceptScore W2897801044C552990157 @default.
• W2897801044 hasConceptScore W2897801044C55493867 @default.
• W2897801044 hasConceptScore W2897801044C86803240 @default.
• W2897801044 hasFunder F4320321091 @default.
• W2897801044 hasFunder F4320322025 @default.
• W2897801044 hasFunder F4320324953 @default.
• W2897801044 hasLocation W28978010441 @default.
• W2897801044 hasLocation W28978010442 @default.

• next