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- W2897808317 endingPage "3159" @default.
- W2897808317 startingPage "3159" @default.
- W2897808317 abstract "The magnetization of mesenchymal stem cells (MSC) has the potential to aid tissue engineering approaches by allowing tracking, targeting, and local retention of cells at the site of tissue damage. Commonly used methods for magnetizing cells include optimizing uptake and retention of superparamagnetic iron oxide nanoparticles (SPIONs). These appear to have minimal detrimental effects on the use of MSC function as assessed by in vitro assays. The cellular content of magnetic nanoparticles (MNPs) will, however, decrease with cell proliferation and the longer-term effects on MSC function are not entirely clear. An alternative approach to magnetizing MSCs involves genetic modification by transfection with one or more genes derived from Magnetospirillum magneticum AMB-1, a magnetotactic bacterium that synthesizes single-magnetic domain crystals which are incorporated into magnetosomes. MSCs with either or mms6 and mmsF genes are followed by bio-assimilated synthesis of intracytoplasmic magnetic nanoparticles which can be imaged by magnetic resonance (MR) and which have no deleterious effects on MSC proliferation, migration, or differentiation. The stable transfection of magnetosome-associated genes in MSCs promotes assimilation of magnetic nanoparticle synthesis into mammalian cells with the potential to allow MR-based cell tracking and, through external or internal magnetic targeting approaches, enhanced site-specific retention of cells for tissue engineering." @default.
- W2897808317 created "2018-10-26" @default.
- W2897808317 creator A5012307458 @default.
- W2897808317 creator A5026600482 @default.
- W2897808317 creator A5039338150 @default.
- W2897808317 creator A5045237640 @default.
- W2897808317 date "2018-10-14" @default.
- W2897808317 modified "2023-10-05" @default.
- W2897808317 title "The Potential of Intrinsically Magnetic Mesenchymal Stem Cells for Tissue Engineering" @default.
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