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- W2897810065 abstract "Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells facilitating cancer development and progression. Oncogene-driven metabolic reprogramming modifies the epigenetic landscape through DNA and histone modification enzymes modulation. Conversely, epigenetic mechanisms regulate the expression of metabolism-related genes, promoting the well-known metabolic reprogramming of cancer cells and, consequently, changing the metabolome. Thus, epigenetic-metabolomic interplay plays a critical role in tumorigenesis by co-ordinately sustaining cell proliferation, metastasis and pluripotency. In this review we emphasize the importance of tumour metabolites in the activity of most chromatin-modifying enzymes and their underlying role in tumorigenesis. Furthermore, we highlight promising molecular targets in tumour metabolism as well as in the epigenetic machinery, focusing on development of small molecules or biologic inhibitors that counteract the epigenomic-metabolic interplay in cancer." @default.
- W2897810065 created "2018-10-26" @default.
- W2897810065 creator A5023725048 @default.
- W2897810065 creator A5042199157 @default.
- W2897810065 creator A5047929505 @default.
- W2897810065 creator A5057879270 @default.
- W2897810065 date "2018-10-09" @default.
- W2897810065 modified "2023-10-10" @default.
- W2897810065 title "Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets" @default.
- W2897810065 cites W1483212110 @default.
- W2897810065 cites W1525752918 @default.
- W2897810065 cites W1553155385 @default.
- W2897810065 cites W1590981211 @default.
- W2897810065 cites W1698690171 @default.
- W2897810065 cites W1817033456 @default.
- W2897810065 cites W1831033366 @default.
- W2897810065 cites W1897302030 @default.
- W2897810065 cites W1916910865 @default.
- W2897810065 cites W1947212643 @default.
- W2897810065 cites W1954584384 @default.
- W2897810065 cites W1959721425 @default.
- W2897810065 cites W1965262464 @default.
- W2897810065 cites W1966447268 @default.
- W2897810065 cites W1968931043 @default.
- W2897810065 cites W1971596685 @default.
- W2897810065 cites W1971992755 @default.
- W2897810065 cites W1972254548 @default.
- W2897810065 cites W1972846893 @default.
- W2897810065 cites W1975227141 @default.
- W2897810065 cites W1975232450 @default.
- W2897810065 cites W1977622464 @default.
- W2897810065 cites W1979658237 @default.
- W2897810065 cites W1981223981 @default.
- W2897810065 cites W1982158297 @default.
- W2897810065 cites W1984600164 @default.
- W2897810065 cites W1984882020 @default.
- W2897810065 cites W1985159629 @default.
- W2897810065 cites W1988756388 @default.
- W2897810065 cites W1989674299 @default.
- W2897810065 cites W1991429659 @default.
- W2897810065 cites W1992902970 @default.
- W2897810065 cites W1993038196 @default.
- W2897810065 cites W1994687037 @default.
- W2897810065 cites W1995338702 @default.
- W2897810065 cites W1995675594 @default.
- W2897810065 cites W1996831788 @default.
- W2897810065 cites W2001624798 @default.
- W2897810065 cites W2004045970 @default.
- W2897810065 cites W2004380688 @default.
- W2897810065 cites W2009188592 @default.
- W2897810065 cites W2009858080 @default.
- W2897810065 cites W2011376105 @default.
- W2897810065 cites W2012388327 @default.
- W2897810065 cites W2013485159 @default.
- W2897810065 cites W2014409119 @default.
- W2897810065 cites W2015755329 @default.
- W2897810065 cites W2016752484 @default.
- W2897810065 cites W2016849135 @default.
- W2897810065 cites W2020196369 @default.
- W2897810065 cites W2020531899 @default.
- W2897810065 cites W2022222857 @default.
- W2897810065 cites W2022267544 @default.
- W2897810065 cites W2024243863 @default.
- W2897810065 cites W2024903578 @default.
- W2897810065 cites W2025998934 @default.
- W2897810065 cites W2028791747 @default.
- W2897810065 cites W2033102369 @default.
- W2897810065 cites W2033790504 @default.
- W2897810065 cites W2033807650 @default.
- W2897810065 cites W2034667463 @default.
- W2897810065 cites W2035010201 @default.
- W2897810065 cites W2038907283 @default.
- W2897810065 cites W2042386784 @default.
- W2897810065 cites W2044055595 @default.
- W2897810065 cites W2044897645 @default.
- W2897810065 cites W2046120998 @default.
- W2897810065 cites W2046241907 @default.
- W2897810065 cites W2047867594 @default.
- W2897810065 cites W2049923433 @default.
- W2897810065 cites W2050140657 @default.
- W2897810065 cites W2050532980 @default.
- W2897810065 cites W2051181260 @default.
- W2897810065 cites W2055237453 @default.
- W2897810065 cites W2055397908 @default.
- W2897810065 cites W2056174640 @default.
- W2897810065 cites W2057139407 @default.
- W2897810065 cites W2058836646 @default.
- W2897810065 cites W2061457471 @default.
- W2897810065 cites W2061576857 @default.
- W2897810065 cites W2061662711 @default.
- W2897810065 cites W2064442490 @default.
- W2897810065 cites W2064807393 @default.
- W2897810065 cites W2067708335 @default.
- W2897810065 cites W2070739037 @default.
- W2897810065 cites W2072451938 @default.
- W2897810065 cites W2072844557 @default.
- W2897810065 cites W2074696167 @default.
- W2897810065 cites W2075360559 @default.
- W2897810065 cites W2076427233 @default.
- W2897810065 cites W2078972833 @default.