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- W2897818944 abstract "H4octox, a versatile new octadentate acyclic chelating ligand, has been investigated as an alternative to the acyclic DTPA and the macrocyclic DOTA for trivalent metal ions useful in diagnostic medical imaging or therapeutic applications (Y3+, In3+, La3+, Gd3+, Lu3+). The synthesis of H4octox is straightforward in less steps and thus more economical than those of most previously reported chelators. Complex formation equilibria in the presence of Y3+, In3+, La3+, Gd3+, and Lu3+ revealed fast chelation and high metal-sequestering capacity. Quantitative labeling with 111In3+ was achieved within 15 min at room temperature at ligand concentrations as low as 10–7 M, exactly the properties required for the development of kit-based radiopharmaceuticals. In vitro serum stability studies and in vivo SPECT imaging confirmed excellent complex stability of [111In(octox)]−. Moreover, it is more lipophilic than most of the multidentate carboxylate- or picolinate-based chelators; it therefore shows more liver clearance and provides a complementary choice in the design of metal-based pharmaceuticals and in the tuning of their pharmacokinetic properties. Finally, H4octox showed a large fluorescence enhancement upon complexation with different metals, in particular, with Y3+ and Lu3+, which could be useful for non-radioactive fluorescent stability and cell studies as well as bimodal imaging. Excellent in vitro stability of [Y(octox)]− against transferrin and Fe3+ was confirmed employing this fluorescence." @default.
- W2897818944 created "2018-10-26" @default.
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- W2897818944 date "2018-10-16" @default.
- W2897818944 modified "2023-10-16" @default.
- W2897818944 title "H<sub>4</sub>octox: Versatile Bimodal Octadentate Acyclic Chelating Ligand for Medicinal Inorganic Chemistry" @default.
- W2897818944 cites W1542976343 @default.
- W2897818944 cites W1966182479 @default.
- W2897818944 cites W1966335626 @default.
- W2897818944 cites W1969360633 @default.
- W2897818944 cites W1984505177 @default.
- W2897818944 cites W1985478695 @default.
- W2897818944 cites W1985533665 @default.
- W2897818944 cites W2000089902 @default.
- W2897818944 cites W2002852719 @default.
- W2897818944 cites W2008299344 @default.
- W2897818944 cites W2011884743 @default.
- W2897818944 cites W2016034351 @default.
- W2897818944 cites W2019452663 @default.
- W2897818944 cites W2020243879 @default.
- W2897818944 cites W2024175762 @default.
- W2897818944 cites W2030890093 @default.
- W2897818944 cites W2031026334 @default.
- W2897818944 cites W2035599506 @default.
- W2897818944 cites W2043601120 @default.
- W2897818944 cites W2044490585 @default.
- W2897818944 cites W2045844438 @default.
- W2897818944 cites W2054649333 @default.
- W2897818944 cites W2057426811 @default.
- W2897818944 cites W2059205366 @default.
- W2897818944 cites W2060444474 @default.
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- W2897818944 cites W2068617439 @default.
- W2897818944 cites W206963652 @default.
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- W2897818944 cites W2132454074 @default.
- W2897818944 cites W2138520198 @default.
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- W2897818944 cites W2334371566 @default.
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- W2897818944 cites W2558622223 @default.
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- W2897818944 cites W2749964508 @default.
- W2897818944 cites W2772848330 @default.
- W2897818944 cites W2783227529 @default.
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- W2897818944 doi "https://doi.org/10.1021/jacs.8b09964" @default.
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