FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897822475> ?p ?o ?g. }

• W2897822475 abstract "Activation of the immune system induces rapid reductions in hypothalamic-pituitary-gonadal (HPG) axis activity, which in turn decreases secretion of sex steroids. This response is likely adaptive for survival by temporarily inhibiting reproduction to conserve energy; however, the physiological mechanisms controlling this response remain unclear. The neuropeptide kisspeptin is a candidate to mediate the decrease in sex hormones seen during sickness through its key regulation of the HPG axis. In this study, the effects of acute immune activation on the response to kisspeptin were assessed in male Siberian hamsters (Phodopus sungorus). Specifically, an immune response was induced in animals by a single treatment of lipopolysaccharide (LPS), and reproductive hormone concentrations were determined in response to subsequent injections of exogenous kisspeptin. Saline-treated controls showed a robust increase in circulating testosterone in response to kisspeptin; however, this response was blocked in LPS-treated animals. Circulating luteinizing hormone (LH) levels were elevated in response to kisspeptin in both LPS- and saline-treated groups and, thus, were unaffected by LPS treatment, suggesting gonad-level inhibition of testosterone release despite central HPG activation. In addition, blockade of glucocorticoid receptors by mifepristone did not attenuate the LPS-induced inhibition of testosterone release, suggesting that circulating glucocorticoids do not mediate this phenomenon. Collectively, these findings reveal that acute endotoxin exposure rapidly renders the gonads less sensitive to HPG stimulation, thus effectively inhibiting sex hormone release. More broadly, these results shed light on the effects of immune activation on the HPG axis and help elucidate the mechanisms controlling energy allocation and reproduction." @default.
• W2897822475 created "2018-10-26" @default.
• W2897822475 creator A5015518126 @default.
• W2897822475 creator A5026100762 @default.
• W2897822475 creator A5029757723 @default.
• W2897822475 creator A5080828891 @default.
• W2897822475 creator A5087350715 @default.
• W2897822475 date "2018-01-01" @default.
• W2897822475 modified "2023-09-27" @default.
• W2897822475 title "Endotoxin rapidly desensitizes the gonads to kisspeptin-induced luteinizing hormone release in male Siberian hamsters (Phodopus sungorus)" @default.
• W2897822475 cites W148231546 @default.
• W2897822475 cites W1498787775 @default.
• W2897822475 cites W1967547663 @default.
• W2897822475 cites W1969066675 @default.
• W2897822475 cites W1969254161 @default.
• W2897822475 cites W1971133818 @default.
• W2897822475 cites W1975440248 @default.
• W2897822475 cites W1975890243 @default.
• W2897822475 cites W1978778149 @default.
• W2897822475 cites W1982027478 @default.
• W2897822475 cites W1996084795 @default.
• W2897822475 cites W1996826305 @default.
• W2897822475 cites W2004489427 @default.
• W2897822475 cites W2004945873 @default.
• W2897822475 cites W2009424714 @default.
• W2897822475 cites W2009659460 @default.
• W2897822475 cites W2013524799 @default.
• W2897822475 cites W2013589853 @default.
• W2897822475 cites W2013980575 @default.
• W2897822475 cites W2014113039 @default.
• W2897822475 cites W2023637447 @default.
• W2897822475 cites W2028777780 @default.
• W2897822475 cites W2033153724 @default.
• W2897822475 cites W2042661460 @default.
• W2897822475 cites W2045512007 @default.
• W2897822475 cites W2054579575 @default.
• W2897822475 cites W2056688614 @default.
• W2897822475 cites W2060679918 @default.
• W2897822475 cites W2066166647 @default.
• W2897822475 cites W2076167864 @default.
• W2897822475 cites W2077979615 @default.
• W2897822475 cites W2083855888 @default.
• W2897822475 cites W2091398724 @default.
• W2897822475 cites W2091607606 @default.
• W2897822475 cites W2091975706 @default.
• W2897822475 cites W2095147906 @default.
• W2897822475 cites W2097516685 @default.
• W2897822475 cites W2099555137 @default.
• W2897822475 cites W2100733933 @default.
• W2897822475 cites W2101577937 @default.
• W2897822475 cites W2102677667 @default.
• W2897822475 cites W2106483505 @default.
• W2897822475 cites W2111201023 @default.
• W2897822475 cites W2111824942 @default.
• W2897822475 cites W2130171711 @default.
• W2897822475 cites W2139371826 @default.
• W2897822475 cites W2142650429 @default.
• W2897822475 cites W2145890122 @default.
• W2897822475 cites W2150974178 @default.
• W2897822475 cites W2165636895 @default.
• W2897822475 cites W2167422272 @default.
• W2897822475 cites W2183557415 @default.
• W2897822475 cites W2471171793 @default.
• W2897822475 cites W2522571887 @default.
• W2897822475 cites W2750917423 @default.
• W2897822475 cites W776740882 @default.
• W2897822475 doi "https://doi.org/10.1242/jeb.185504" @default.
• W2897822475 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6288069" @default.
• W2897822475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30297514" @default.
• W2897822475 hasPublicationYear "2018" @default.
• W2897822475 type Work @default.
• W2897822475 sameAs 2897822475 @default.
• W2897822475 citedByCount "4" @default.
• W2897822475 countsByYear W28978224752020 @default.
• W2897822475 countsByYear W28978224752022 @default.
• W2897822475 crossrefType "journal-article" @default.
• W2897822475 hasAuthorship W2897822475A5015518126 @default.
• W2897822475 hasAuthorship W2897822475A5026100762 @default.
• W2897822475 hasAuthorship W2897822475A5029757723 @default.
• W2897822475 hasAuthorship W2897822475A5080828891 @default.
• W2897822475 hasAuthorship W2897822475A5087350715 @default.
• W2897822475 hasBestOaLocation W28978224751 @default.
• W2897822475 hasConcept C126322002 @default.
• W2897822475 hasConcept C134018914 @default.
• W2897822475 hasConcept C146819174 @default.
• W2897822475 hasConcept C203014093 @default.
• W2897822475 hasConcept C2776808119 @default.
• W2897822475 hasConcept C2778575167 @default.
• W2897822475 hasConcept C2778575703 @default.
• W2897822475 hasConcept C2778754761 @default.
• W2897822475 hasConcept C2778894405 @default.
• W2897822475 hasConcept C2779279991 @default.
• W2897822475 hasConcept C2780570174 @default.
• W2897822475 hasConcept C2780841215 @default.
• W2897822475 hasConcept C71315377 @default.
• W2897822475 hasConcept C71924100 @default.
• W2897822475 hasConcept C86803240 @default.
• W2897822475 hasConcept C8891405 @default.
• W2897822475 hasConceptScore W2897822475C126322002 @default.
• W2897822475 hasConceptScore W2897822475C134018914 @default.

• next