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• W2897825535 abstract "Target-specific killing of tumor cells with antibody-drug conjugates (ADCs) is an elegant concept in the continued fight against cancer. However, despite more than 20 years of clinical development, only four ADC have reached market approval, while at least 50 clinical programs were terminated early. The high attrition rate of ADCs may, at least in part, be attributed to heterogeneity and instability of conventional technologies. At present, various (chemo)enzymatic approaches for site-specific and stable conjugation of toxic payloads are making their way to the clinic, thereby potentially providing ADCs with increased therapeutic window." @default.
• W2897825535 created "2018-10-26" @default.
• W2897825535 creator A5019427579 @default.
• W2897825535 creator A5054629669 @default.
• W2897825535 date "2018-12-01" @default.
• W2897825535 modified "2023-09-27" @default.
• W2897825535 title "Enzymatic strategies for (near) clinical development of antibody-drug conjugates" @default.
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• W2897825535 doi "https://doi.org/10.1016/j.ddtec.2018.09.005" @default.
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