FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897829536> ?p ?o ?g. }

• W2897829536 abstract "The complement system is a key component of the innate immune system, participating in the surveillance against infectious agents. Once activated by one of the three different pathways, complement mediates cell lysis, opsonization, signalizes pathogens for phagocytosis and induces the adaptive immune response. The lectin pathway is constituted by several soluble and membrane bound proteins, called pattern recognition molecules (PRM), including mannose binding lectin (MBL), Ficolins-1, -2, and -3, and Collectin 11. These PRMs act on complement activation as recognition molecules of pathogen-associated molecular patterns (PAMPs) such as N-acetylated, found in glycoproteins of viral envelopes. In this study, Ficolin-1 and Ficolin-3 plasma levels were evaluated in 178 HIV patients (93 HIV; 85 HIV/HCV) and 85 controls from southern Brazil. Demographic and clinical-laboratory findings were obtained during medical interview and from medical records. All parameters were assessed by logistic regression, adjusted for age, ancestry, and sex. Significantly lower levels of Ficolin-1 were observed in HIV/HCV coinfected when compared to HIV patients (p = 0.005, median = 516 vs. 667 ng/ul, respectively) and to controls (p < 0.0001, 1186 ng/ul). Ficolin-1 levels were lower in males than in females among HIV patients (p = 0.03) and controls (p = 0.0003), but no association of Ficolin-1 levels with AIDS was observed. On the other hand, Ficolin-3 levels were significantly lower in controls when compared to HIV (p < 0.0001, medians 18,240 vs. 44,030 ng/ml, respectively) and HIV/HCV coinfected (p < 0.0001, 40,351 ng/ml) patients. There was no correlation between Ficolin-1 and Ficolin-3 levels and age, HIV viral load or opportunistic infections. However, Ficolin-3 showed a positive correlation with T CD4 cell counts in HIV monoinfected patients (p = 0.007). We provide here the first assessment of Ficolin-1 and-3 levels in HIV and HIV/HCV coinfected patients, which indicates a distinct role for these pattern recognition molecules in both viral infections." @default.
• W2897829536 created "2018-10-26" @default.
• W2897829536 creator A5006404917 @default.
• W2897829536 creator A5029059410 @default.
• W2897829536 creator A5030777834 @default.
• W2897829536 creator A5031508703 @default.
• W2897829536 creator A5038493283 @default.
• W2897829536 creator A5040967172 @default.
• W2897829536 creator A5044402087 @default.
• W2897829536 creator A5045144762 @default.
• W2897829536 creator A5074761424 @default.
• W2897829536 date "2018-10-08" @default.
• W2897829536 modified "2023-09-24" @default.
• W2897829536 title "Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil" @default.
• W2897829536 cites W1970113462 @default.
• W2897829536 cites W1971066039 @default.
• W2897829536 cites W1981324735 @default.
• W2897829536 cites W1983502463 @default.
• W2897829536 cites W1986682502 @default.
• W2897829536 cites W1988163992 @default.
• W2897829536 cites W1988492576 @default.
• W2897829536 cites W2004879434 @default.
• W2897829536 cites W2005044790 @default.
• W2897829536 cites W2012904769 @default.
• W2897829536 cites W2015690645 @default.
• W2897829536 cites W2028717252 @default.
• W2897829536 cites W2045941787 @default.
• W2897829536 cites W2054470549 @default.
• W2897829536 cites W2055151937 @default.
• W2897829536 cites W2062445513 @default.
• W2897829536 cites W2065622508 @default.
• W2897829536 cites W2066582706 @default.
• W2897829536 cites W2070902941 @default.
• W2897829536 cites W2072661867 @default.
• W2897829536 cites W2073640708 @default.
• W2897829536 cites W2084138453 @default.
• W2897829536 cites W2087571895 @default.
• W2897829536 cites W2093471951 @default.
• W2897829536 cites W2102754497 @default.
• W2897829536 cites W2106106907 @default.
• W2897829536 cites W2108206717 @default.
• W2897829536 cites W2133250522 @default.
• W2897829536 cites W2136648677 @default.
• W2897829536 cites W2155204580 @default.
• W2897829536 cites W2156236127 @default.
• W2897829536 cites W2158733025 @default.
• W2897829536 cites W2170805498 @default.
• W2897829536 cites W2321652631 @default.
• W2897829536 cites W2333869345 @default.
• W2897829536 cites W2414515917 @default.
• W2897829536 cites W2515173084 @default.
• W2897829536 cites W2542867039 @default.
• W2897829536 cites W2560021839 @default.
• W2897829536 cites W2594623851 @default.
• W2897829536 cites W2612771207 @default.
• W2897829536 cites W4302196123 @default.
• W2897829536 doi "https://doi.org/10.3389/fimmu.2018.02292" @default.
• W2897829536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6187973" @default.
• W2897829536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30349535" @default.
• W2897829536 hasPublicationYear "2018" @default.
• W2897829536 type Work @default.
• W2897829536 sameAs 2897829536 @default.
• W2897829536 citedByCount "6" @default.
• W2897829536 countsByYear W28978295362019 @default.
• W2897829536 countsByYear W28978295362020 @default.
• W2897829536 countsByYear W28978295362021 @default.
• W2897829536 countsByYear W28978295362022 @default.
• W2897829536 crossrefType "journal-article" @default.
• W2897829536 hasAuthorship W2897829536A5006404917 @default.
• W2897829536 hasAuthorship W2897829536A5029059410 @default.
• W2897829536 hasAuthorship W2897829536A5030777834 @default.
• W2897829536 hasAuthorship W2897829536A5031508703 @default.
• W2897829536 hasAuthorship W2897829536A5038493283 @default.
• W2897829536 hasAuthorship W2897829536A5040967172 @default.
• W2897829536 hasAuthorship W2897829536A5044402087 @default.
• W2897829536 hasAuthorship W2897829536A5045144762 @default.
• W2897829536 hasAuthorship W2897829536A5074761424 @default.
• W2897829536 hasBestOaLocation W28978295361 @default.
• W2897829536 hasConcept C108625454 @default.
• W2897829536 hasConcept C111684460 @default.
• W2897829536 hasConcept C124594742 @default.
• W2897829536 hasConcept C126322002 @default.
• W2897829536 hasConcept C133493029 @default.
• W2897829536 hasConcept C136449434 @default.
• W2897829536 hasConcept C153911025 @default.
• W2897829536 hasConcept C159654299 @default.
• W2897829536 hasConcept C168507396 @default.
• W2897829536 hasConcept C171279029 @default.
• W2897829536 hasConcept C189413060 @default.
• W2897829536 hasConcept C203014093 @default.
• W2897829536 hasConcept C203880312 @default.
• W2897829536 hasConcept C2780758401 @default.
• W2897829536 hasConcept C71924100 @default.
• W2897829536 hasConcept C79196540 @default.
• W2897829536 hasConcept C86803240 @default.
• W2897829536 hasConcept C8891405 @default.
• W2897829536 hasConcept C89372155 @default.
• W2897829536 hasConceptScore W2897829536C108625454 @default.
• W2897829536 hasConceptScore W2897829536C111684460 @default.
• W2897829536 hasConceptScore W2897829536C124594742 @default.

• next