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• W2897830812 abstract "With the simple functionalization method and good biocompatibility, an aptamer-integrated DNA hydrogel is used as the protein delivery system with an adjustable release rate and time by using complementary sequences (CSs) as the biomolecular trigger. The aptamer-functionalized DNA hydrogel was prepared via a one-pot self-assembly process from two kinds of DNA building blocks (X-shaped and L-shaped DNA units) and a single-stranded aptamer. The gelling process was achieved under physiological conditions within one minute. In the absence of the triggering CSs, the aptamer grafted in the hydrogel exhibited a stable state for protein-specific capture. While hybridizing with the triggering CSs, the aptamer is turned into a double-stranded structure, resulting in the fast dissociation of protein with a wise-stage controlled release program. Further, the DNA hydrogel with excellent cytocompatibility has been successfully applied to human serum, forming a complex matrix. The whole process of protein capture and release were biocompatible and could not refer to any adverse factor of the protein or cells. Thus, the aptamer-functionalized DNA hydrogel will be a good candidate for controlled protein delivery." @default.
• W2897830812 created "2018-10-26" @default.
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• W2897830812 date "2018-10-16" @default.
• W2897830812 modified "2023-10-16" @default.
• W2897830812 title "Aptamer Functionalized DNA Hydrogel for Wise-Stage Controlled Protein Release" @default.
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• W2897830812 doi "https://doi.org/10.3390/app8101941" @default.
• W2897830812 hasPublicationYear "2018" @default.
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