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• W2897837063 abstract "Inspired by the concept of molecular hybridization, a series of new isatin‐pomalidomide hybrids ( 9a – 9g ) were designed, synthesized, characterized, and evaluated for in vitro cytotoxic activity against U266B1 and RPMI 8226 multiple myeloma cell lines. Sandmeyer methodology and N‐halomethylketo alkylation reaction are the two important reactions involved in the synthesis of isatin‐pomalidomide hybrids ( 9a – 9g ). All the synthesized compounds ( 3a – 3d , 4 , 5 , 6 , and 9a – 9g ) were characterized by using IR, mass, 1 H‐NMR, and 13 C‐NMR spectral techniques. The efficacy of all the synthesized compounds was tested against the aforementioned cell lines by employing MTT assay (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) standard protocols while using pomalidomide as a standard. The test concentrations used in the MTT assay were 1, 10, 20, 30, and 40 μM, and the period of incubation was 24 h. All the synthesized compounds were found to have moderate to greater cytotoxic activity against the aforementioned cell lines. Among them, synthesized hybrids 9f (IC 50 , U266B1 = 5.15 ± 0.72 μM, RPMI8226 = 11.66 ± 0.79 μM) and 9g (IC 50 , U266B1 = 2.50 ± 0.37 μM, RPMI8226 = 6.70 ± 0.55 μM) displayed better cytotoxic activity against both the cell lines used in the present study." @default.
• W2897837063 created "2018-10-26" @default.
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• W2897837063 date "2018-10-19" @default.
• W2897837063 modified "2023-09-25" @default.
• W2897837063 title "Design, Synthesis, Characterization, and <i>In Vitro</i> Evaluation of Isatin‐Pomalidomide Hybrids for Cytotoxicity against Multiple Myeloma Cell Lines" @default.
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• W2897837063 doi "https://doi.org/10.1002/jhet.3365" @default.
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